| Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue J Gass, MT Bethune, M Siegel, A Spencer, C Khosla Gastroenterology 133 (2), 472-480, 2007 | 284 | 2007 |
| Transglutaminase 2 inhibitors and their therapeutic role in disease states M Siegel, C Khosla Pharmacology & therapeutics 115 (2), 232-245, 2007 | 254 | 2007 |
| Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury M Siegel, P Strnad, RE Watts, K Choi, B Jabri, MB Omary, C Khosla PloS one 3 (3), e1861, 2008 | 247 | 2008 |
| Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2 K Choi, M Siegel, JL Piper, L Yuan, E Cho, P Strnad, B Omary, KM Rich, ... Chemistry & biology 12 (4), 469-475, 2005 | 206 | 2005 |
| Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy L Yuan, M Siegel, K Choi, C Khosla, CR Miller, EN Jackson, ... Oncogene 26 (18), 2563-2573, 2007 | 190 | 2007 |
| Rational design of combination enzyme therapy for celiac sprue M Siegel, MT Bethune, J Gass, J Ehren, J Xia, A Johannsen, TB Stuge, ... Chemistry & biology 13 (6), 649-658, 2006 | 187 | 2006 |
| The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo JA Tye-Din, RP Anderson, RA Ffrench, GJ Brown, P Hodsman, M Siegel, ... Clinical immunology 134 (3), 289-295, 2010 | 172 | 2010 |
| Development and characterization of a human and mouse intestinal epithelial cell monolayer platform K Kozuka, Y He, S Koo-McCoy, P Kumaraswamy, B Nie, K Shaw, P Chan, ... Stem cell reports 9 (6), 1976-1990, 2017 | 153 | 2017 |
| Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue GG Pyle, B Paaso, BE Anderson, DD Allen, T Marti, Q Li, M Siegel, ... Clinical Gastroenterology and Hepatology 3 (7), 687-694, 2005 | 142 | 2005 |
| Safety, tolerability, and activity of ALV003: results from two phase 1 single, escalating-dose clinical trials M Siegel, ME Garber, AG Spencer, W Botwick, P Kumar, RN Williams, ... Digestive diseases and sciences 57, 440-450, 2012 | 120 | 2012 |
| Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease J Xia, E Bergseng, B Fleckenstein, M Siegel, CY Kim, C Khosla, LM Sollid Bioorganic & medicinal chemistry 15 (20), 6565-6573, 2007 | 115 | 2007 |
| Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability AJ King, M Siegel, Y He, B Nie, J Wang, S Koo-McCoy, NA Minassian, ... Science translational medicine 10 (456), eaam6474, 2018 | 111 | 2018 |
| Structure− activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles RE Watts, M Siegel, C Khosla Journal of medicinal chemistry 49 (25), 7493-7501, 2006 | 102 | 2006 |
| Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from α2-gliadin J Xia, M Siegel, E Bergseng, LM Sollid, C Khosla Journal of the American Chemical Society 128 (6), 1859-1867, 2006 | 94 | 2006 |
| Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice PD Finn, D Rodriguez, J Kohler, Z Jiang, S Wan, E Blanco, AJ King, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 316 (3 …, 2019 | 76 | 2019 |
| Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement P Strnad, M Harada, M Siegel, RA Terkeltaub, RM Graham, C Khosla, ... Gastroenterology 132 (4), 1515-1526, 2007 | 71 | 2007 |
| Structure-based design of α-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2 M Siegel, J Xia, C Khosla Bioorganic & medicinal chemistry 15 (18), 6253-6261, 2007 | 53 | 2007 |
| Interferon-γ released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides MT Bethune, M Siegel, S Howles-Banerji, C Khosla Journal of Pharmacology and Experimental Therapeutics 329 (2), 657-668, 2009 | 46 | 2009 |
| Peptides for diagnostic and therapeutic methods for celiac sprue C Khosla, J Xia, MJ Siegel US Patent 7,462,688, 2008 | 46 | 2008 |
| Transglutaminase inhibitors and methods of use thereof C Khosla, RE Watts, MJ Siegel, DM Pinkas, K Choi, KM Rich US Patent 7,579,313, 2009 | 34 | 2009 |
