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Henrik Cordes
Henrik Cordes
Sanofi - DMPK Germany
Verified email at sanofi.com - Homepage
Title
Cited by
Cited by
Year
A physiologically based pharmacokinetic model of isoniazid and its application in individualizing tuberculosis chemotherapy
H Cordes, C Thiel, HE Aschmann, V Baier, LM Blank, L Kuepfer
Antimicrobial agents and chemotherapy 60 (10), 6134-6145, 2016
532016
Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation
H Cordes, C Thiel, V Baier, LM Blank, L Kuepfer
NPJ systems biology and applications 4 (1), 10, 2018
352018
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling
M Verheijen, Y Schrooders, H Gmuender, R Nudischer, O Clayton, ...
Toxicology letters 294, 184-192, 2018
342018
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity
L Kuepfer, O Clayton, C Thiel, H Cordes, R Nudischer, LM Blank, V Baier, ...
Archives of toxicology 92, 553-555, 2018
342018
Network integration and modelling of dynamic drug responses at multi-omics levels
N Selevsek, F Caiment, R Nudischer, H Gmuender, I Agarkova, ...
Communications biology 3 (1), 573, 2020
302020
A 3D heterotypic multicellular tumor spheroid assay platform to discriminate drug effects on stroma versus cancer cells
Z Weydert, M Lal-Nag, L Mathews-Greiner, C Thiel, H Cordes, L Küpfer, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (3), 265-276, 2020
222020
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
C Thiel, H Cordes, I Conde, JV Castell, LM Blank, L Kuepfer
Archives of toxicology 91, 865-883, 2017
222017
A comparative analysis of drug-induced hepatotoxicity in clinically relevant situations
C Thiel, H Cordes, L Fabbri, HE Aschmann, V Baier, I Smit, F Atkinson, ...
PLoS computational biology 13 (2), e1005280, 2017
182017
Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations
C Thiel, I Smit, V Baier, H Cordes, B Fabry, LM Blank, L Kuepfer
NPJ systems biology and applications 4 (1), 28, 2018
162018
A physiology-based model of human bile acid metabolism for predicting bile acid tissue levels after drug administration in healthy subjects and BRIC type 2 patients
V Baier, H Cordes, UP Neumann, L Kuepfer
Frontiers in physiology 10, 455116, 2019
152019
Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen‐induced toxicity in humans
C Thiel, H Cordes, V Baier, LM Blank, L Kuepfer
CPT: pharmacometrics & systems pharmacology 6 (2), 136-146, 2017
112017
Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species
H Cordes, H Rapp
CPT: Pharmacometrics & Systems Pharmacology 12 (3), 311-319, 2023
42023
A model‐based workflow to benchmark the clinical cholestasis risk of drugs
V Baier, O Clayton, R Nudischer, H Cordes, ARP Schneider, C Thiel, ...
Clinical Pharmacology & Therapeutics 110 (5), 1293-1301, 2021
42021
A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups
V Baier, H Cordes, C Thiel, U Neumann, LM Blank, L Kuepfer
bioRxiv, 450965, 2018
32018
Multi-scale modeling in human systems pharmacology & physiology
H Cordes, J Sáez Rodríguez, LM Blank
Fachgruppe Biologie, 2019
12019
Modellierung metabolischer Netzwerke im menschlichen Körper: Systembiologie
H Cordes, C Thiel, LM Blank, L Küpfer
BIOspektrum 20, 39-41, 2014
12014
MULTI-SCALE PHYSIOLOGICALLY-BASED QUANTITATIVE SYSTEMS PHARMACOLOGY MODELING FOR SIMULATING CELLULAR DRUG RESPONSES WITHIN A WHOLE-BODY CONTEXT.
V Baier, C Thiel, H Cordes, L Blank, L Kuepfer
CLINICAL PHARMACOLOGY & THERAPEUTICS 105, S30-S30, 2019
2019
Edaravone medication is known to be an antioxidant, and oxidative stress has been hypothesized to be part of the process that kills neurons in people with ALS Menu
V Baier, O Clayton, R Nudischer, H Cordes, ARP Schneider, C Thiel, ...
A PBPK Model of Isoniazid and its Application in Individualizing Tuberculosis Chemotherapy
H Cordes, C Thiel, HM Aschmann, V Baier, L Blank, L Kuepfer
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