Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity X Jiang, RA Clark, L Liu, AJ Wagers, RC Fuhlbrigge, TS Kupper Nature 483 (7388), 227-231, 2012 | 947 | 2012 |
The vast majority of CLA+ T cells are resident in normal skin RA Clark, B Chong, N Mirchandani, NK Brinster, K Yamanaka, ... The Journal of Immunology 176 (7), 4431-4439, 2006 | 919 | 2006 |
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism Y Pan, T Tian, CO Park, SY Lofftus, S Mei, X Liu, C Luo, JT O’Malley, ... Nature 543 (7644), 252-256, 2017 | 617 | 2017 |
Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells R Watanabe, A Gehad, C Yang, LL Scott, JE Teague, C Schlapbach, ... Science translational medicine 7 (279), 279ra39-279ra39, 2015 | 567 | 2015 |
Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors JJ Campbell, RA Clark, R Watanabe, TS Kupper Blood, The Journal of the American Society of Hematology 116 (5), 767-771, 2010 | 540 | 2010 |
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells J Seneschal, RA Clark, A Gehad, CM Baecher-Allan, TS Kupper Immunity 36 (5), 873-884, 2012 | 510 | 2012 |
Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells R Purwar, C Schlapbach, S Xiao, HS Kang, W Elyaman, X Jiang, ... Nature medicine 18 (8), 1248-1253, 2012 | 485 | 2012 |
Resident memory T cells in human health and disease RA Clark Science translational medicine 7 (269), 269rv1-269rv1, 2015 | 457 | 2015 |
Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients RA Clark, R Watanabe, JE Teague, C Schlapbach, MC Tawa, N Adams, ... Science translational medicine 4 (117), 117ra7-117ra7, 2012 | 382 | 2012 |
Old meets new: the interaction between innate and adaptive immunity R Clark, T Kupper Journal of Investigative Dermatology 125 (4), 629-637, 2005 | 367 | 2005 |
The majority of human peripheral blood CD4+ CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors K Hirahara, L Liu, RA Clark, K Yamanaka, RC Fuhlbrigge, TS Kupper The Journal of Immunology 177 (7), 4488-4494, 2006 | 365 | 2006 |
Skin-resident T cells: the ups and downs of on site immunity RA Clark Journal of Investigative Dermatology 130 (2), 362-370, 2010 | 361 | 2010 |
Resident Memory T Cells (TRM) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity R Purwar, J Campbell, G Murphy, WG Richards, RA Clark, TS Kupper PloS one 6 (1), e16245, 2011 | 356 | 2011 |
CD8+ T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22 DJ Hijnen, EF Knol, YY Gent, B Giovannone, SJP Beijn, TS Kupper, ... Journal of Investigative Dermatology 133 (4), 973-979, 2013 | 338 | 2013 |
The public repository of xenografts enables discovery and randomized phase II-like trials in mice EC Townsend, MA Murakami, A Christodoulou, AL Christie, J Köster, ... Cancer cell 29 (4), 574-586, 2016 | 328 | 2016 |
Common clonal origin of central and resident memory T cells following skin immunization O Gaide, RO Emerson, X Jiang, N Gulati, S Nizza, C Desmarais, H Robins, ... Nature medicine 21 (6), 647-653, 2015 | 302 | 2015 |
An investigation into the dynamic effects on the track of wheelflats on railway vehicles SG Newton, RA Clark Journal of Mechanical Engineering Science 21 (4), 287-297, 1979 | 300 | 1979 |
CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire A De Jong, V Peña-Cruz, TY Cheng, RA Clark, I Van Rhijn, DB Moody Nature immunology 11 (12), 1102-1109, 2010 | 280 | 2010 |
Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones TR Matos, JT O’Malley, EL Lowry, D Hamm, IR Kirsch, HS Robins, ... The Journal of clinical investigation 127 (11), 4031-4041, 2017 | 252 | 2017 |
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells RA Clark, SJ Huang, GF Murphy, IG Mollet, D Hijnen, M Muthukuru, ... The Journal of experimental medicine 205 (10), 2221-2234, 2008 | 245 | 2008 |