| Elucidating the role of site-specific nitration of α-synuclein in the pathogenesis of Parkinson’s disease via protein semisynthesis and mutagenesis R Burai, N Ait-Bouziad, A Chiki, HA Lashuel Journal of the American Chemical Society 137 (15), 5041-5052, 2015 | 167 | 2015 |
| Nanoscale studies link amyloid maturity with polyglutamine diseases onset FS Ruggeri, S Vieweg, U Cendrowska, G Longo, A Chiki, HA Lashuel, ... Scientific reports 6 (1), 31155, 2016 | 147 | 2016 |
| Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity AD Stephens, M Zacharopoulou, R Moons, G Fusco, N Seetaloo, A Chiki, ... Nature communications 11 (1), 2820, 2020 | 110 | 2020 |
| N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting SM DeGuire, FS Ruggeri, MB Fares, A Chiki, U Cendrowska, G Dietler, ... Journal of Biological Chemistry 293 (48), 18540-18558, 2018 | 70 | 2018 |
| Mutant Exon1 huntingtin aggregation is regulated by T3 phosphorylation‐induced structural changes and crosstalk between T3 phosphorylation and acetylation at K6 A Chiki, SM DeGuire, FS Ruggeri, D Sanfelice, A Ansaloni, ZM Wang, ... Angewandte Chemie International Edition 56 (19), 5202-5207, 2017 | 65 | 2017 |
| Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation C Cariulo, L Azzollini, M Verani, P Martufi, R Boggio, A Chiki, SM Deguire, ... Proceedings of the National Academy of Sciences 114 (50), E10809-E10818, 2017 | 56 | 2017 |
| A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving … ST Kumar, S Donzelli, A Chiki, MMK Syed, HA Lashuel Journal of neurochemistry 153 (1), 103-119, 2020 | 53 | 2020 |
| Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM U Cendrowska, PJ Silva, N Ait-Bouziad, M Müller, ZP Guven, S Vieweg, ... Proceedings of the National Academy of Sciences 117 (12), 6866-6874, 2020 | 53 | 2020 |
| The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions AL Mahul-Mellier, MF Altay, J Burtscher, N Maharjan, N Ait-Bouziad, ... BioRxiv, 500058, 2018 | 45 | 2018 |
| Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule-and lipid-binding properties of Tau N Ait-Bouziad, A Chiki, G Limorenko, S Xiao, D Eliezer, HA Lashuel Journal of Biological Chemistry 295 (23), 7905-7922, 2020 | 39 | 2020 |
| Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology J Burtscher, JC Copin, J Rodrigues, ST Kumar, A Chiki, IG de Suduiraut, ... Neurobiology of aging 83, 11-20, 2019 | 39 | 2019 |
| TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models RN Hegde, A Chiki, L Petricca, P Martufi, N Arbez, L Mouchiroud, ... The EMBO journal 39 (17), e104671, 2020 | 36 | 2020 |
| Exploring the role of post‐translational modifications in regulating α‐synuclein interactions by studying the effects of phosphorylation on nanobody binding F El Turk, E De Genst, T Guilliams, B Fauvet, M Hejjaoui, J Di Trani, ... Protein Science 27 (7), 1262-1274, 2018 | 26 | 2018 |
| The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1 S Vieweg, AL Mahul-Mellier, FS Ruggeri, N Riguet, SM DeGuire, A Chiki, ... Journal of Molecular Biology 433 (21), 167222, 2021 | 20* | 2021 |
| Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases A Chiki, J Ricci, R Hegde, LA Abriata, A Reif, D Boudeffa, HA Lashuel Chembiochem 22 (1), 217-231, 2021 | 19 | 2021 |
| Generation of native, untagged huntingtin Exon1 monomer and fibrils using a SUMO fusion strategy A Reif, A Chiki, J Ricci, HA Lashuel JoVE (Journal of Visualized Experiments), e57506, 2018 | 18 | 2018 |
| Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity HA Lashuel, AL Mahul-Mellier, S Novello, RN Hegde, Y Jasiqi, MF Altay, ... npj Parkinson's Disease 8 (1), 136, 2022 | 16 | 2022 |
| Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates F Herrmann, M Hessmann, S Schaertl, K Berg-Rosseburg, CJ Brown, ... Scientific Reports 11 (1), 17977, 2021 | 16 | 2021 |
| Structural basis of huntingtin fibril polymorphism revealed by cryogenic electron microscopy of exon 1 HTT fibrils S Nazarov, A Chiki, D Boudeffa, HA Lashuel Journal of the American Chemical Society 144 (24), 10723-10735, 2022 | 15 | 2022 |
| Investigating crosstalk among PTMs provides novel insight into the structural basis underlying the differential effects of Nt17 PTMs on mutant Httex1 aggregation A Chiki, Z Zhang, K Rajasekhar, LA Abriata, I Rostami, LF Krapp, ... Frontiers in molecular biosciences 8, 686086, 2021 | 6 | 2021 |
