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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential OV Evgenov, P Pacher, PM Schmidt, G Haskó, HHHW Schmidt, JP Stasch Nature reviews Drug discovery 5 (9), 755-768, 2006 | 918 | 2006 |
Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease JP Stasch, P Pacher, OV Evgenov Circulation 123 (20), 2263-2273, 2011 | 672 | 2011 |
NO-independent regulatory site on soluble guanylate cyclase JP Stasch, EM Becker, C Alonso-Alija, H Apeler, K Dembowsky, A Feurer, ... Nature 410 (6825), 212, 2001 | 648 | 2001 |
The concise guide to pharmacology 2019/20: Enzymes SPH Alexander, D Fabbro, E Kelly, A Mathie, JA Peters, EL Veale, ... British Journal of Pharmacology 176, S297-S396, 2019 | 540 | 2019 |
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels JP Stasch, PM Schmidt, PI Nedvetsky, TY Nedvetskaya, AK HS, S Meurer, ... The Journal of clinical investigation 116 (9), 2552-2561, 2006 | 528 | 2006 |
Kynurenine is an endothelium-derived relaxing factor produced during inflammation Y Wang, H Liu, G McKenzie, PK Witting, JP Stasch, M Hahn, ... Nature medicine 16 (3), 279-285, 2010 | 503 | 2010 |
Continuous-wave Doppler echocardiographic detection of pulmonary regurgitation and its application to noninvasive estimation of pulmonary artery pressure. T Masuyama, K Kodama, A Kitabatake, H Sato, S Nanto, M Inoue Circulation 74 (3), 484-492, 1986 | 494* | 1986 |
NO‐and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle JP Stasch, P Schmidt, C Alonso‐Alija, H Apeler, K Dembowsky, M Haerter, ... British journal of pharmacology 136 (5), 773-783, 2002 | 399 | 2002 |
The concise guide to pharmacology 2021/22: Enzymes SPH Alexander, D Fabbro, E Kelly, A Mathie, JA Peters, EL Veale, ... British journal of pharmacology 178, S313-S411, 2021 | 380 | 2021 |
Effect of YC‐1, an NO‐independent, superoxide‐sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators A Mülsch, J Bauersachs, A Schäfer, JP Stasch, R Kast, R Busse British journal of pharmacology 120 (4), 681-689, 1997 | 312 | 1997 |
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension RT Schermuly, JP Stasch, SS Pullamsetti, R Middendorff, D Müller, ... European Respiratory Journal 32 (4), 881-891, 2008 | 305 | 2008 |
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling R Dumitrascu, N Weissmann, HA Ghofrani, E Dony, K Beuerlein, ... Circulation 113 (2), 286-295, 2006 | 294 | 2006 |
NO-independent, haem-dependent soluble guanylate cyclase stimulators JP Stasch, AJ Hobbs cGMP: Generators, Effectors and Therapeutic Implications, 277-308, 2009 | 260 | 2009 |
Discovery of riociguat (BAY 63‐2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension J Mittendorf, S Weigand, C Alonso‐Alija, E Bischoff, A Feurer, M Gerisch, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (5), 853-865, 2009 | 251 | 2009 |
The chemistry and biology of soluble guanylate cyclase stimulators and activators M Follmann, N Griebenow, MG Hahn, I Hartung, FJ Mais, J Mittendorf, ... Angewandte Chemie International Edition 52 (36), 9442-9462, 2013 | 238 | 2013 |
NO-independent stimulators of soluble guanylate cyclase A Straub, JP Stasch, C Alonso-Alija, J Benet-Buchholz, B Ducke, A Feurer, ... Bioorganic & Medicinal Chemistry Letters 11 (6), 781-784, 2001 | 213 | 2001 |
Soluble guanylate cyclase stimulators in pulmonary hypertension JP Stasch, OV Evgenov Pharmacotherapy of Pulmonary Hypertension, 279-313, 2013 | 212 | 2013 |
Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase PM Schmidt, M Schramm, H Schröder, F Wunder, JP Stasch Journal of Biological Chemistry 279 (4), 3025-3032, 2004 | 206 | 2004 |
Discovery of the soluble guanylate cyclase stimulator vericiguat (BAY 1021189) for the treatment of chronic heart failure M Follmann, J Ackerstaff, G Redlich, F Wunder, D Lang, A Kern, P Fey, ... Journal of medicinal chemistry 60 (12), 5146-5161, 2017 | 192 | 2017 |