Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. B Sarkadi, EM Price, RC Boucher, UA Germann, GA Scarborough Journal of Biological Chemistry 267 (7), 4854-4858, 1992 | 796 | 1992 |
Fluorescent cellular indicators are extruded by the multidrug resistance protein. L Homolya, Z Holló, UA Germann, I Pastan, MM Gottesman, B Sarkadi Journal of Biological Chemistry 268 (29), 21493-21496, 1993 | 625 | 1993 |
Genetic analysis of the multidrug transporter MM Gottesman, CA Hrycyna, PV Schoenlein, UA Germann, I Pastan Annual review of genetics 29 (1), 607-649, 1995 | 622 | 1995 |
P-glycoprotein—a mediator of multidrug resistance in tumour cells UA Germann European Journal of Cancer 32 (6), 927-944, 1996 | 573 | 1996 |
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation Y Yao, W Li, J Wu, UA Germann, MSS Su, K Kuida, DM Boucher Proceedings of the National Academy of Sciences 100 (22), 12759-12764, 2003 | 429 | 2003 |
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3, 3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R, 3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765 … W Wannamaker, R Davies, M Namchuk, J Pollard, P Ford, G Ku, C Decker, ... Journal of Pharmacology and Experimental Therapeutics 321 (2), 509-516, 2007 | 281 | 2007 |
Two different regions of phosphoglycoprotein are photoaffinity-labeled by azidopine EP Bruggemann, UA Germann, MM Gottesman, I Pastan Journal of Biological Chemistry 264 (26), 15483-15488, 1989 | 245 | 1989 |
Characterization of two allelic forms of Neurospora crassa laccase. Amino-and carboxyl-terminal processing of a precursor. UA Germann, G Müller, PE Hunziker, K Lerch Journal of Biological Chemistry 263 (2), 885-896, 1988 | 238 | 1988 |
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase T Fox, JT Coll, X Xie, PJ Ford, UA Germann, MD Porter, S Pazhanisamy, ... Protein Science 7 (11), 2249-2255, 1998 | 237 | 1998 |
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2 MP Clark, MW Ledeboer, I Davies, RA Byrn, SM Jones, E Perola, A Tsai, ... Journal of medicinal chemistry 57 (15), 6668-6678, 2014 | 220 | 2014 |
Targeting the MAPK signaling pathway in cancer: promising preclinical activity with the novel selective ERK1/2 inhibitor BVD-523 (ulixertinib) UA Germann, BF Furey, W Markland, RR Hoover, AM Aronov, JJ Roix, ... Molecular cancer therapeutics 16 (11), 2351-2363, 2017 | 217 | 2017 |
Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells (∗) UA Germann, TC Chambers, SV Ambudkar, T Licht, CO Cardarelli, ... Journal of Biological Chemistry 271 (3), 1708-1716, 1996 | 215 | 1996 |
P-glycoproteins: mediators of multidrug resistance UA Germann, I Pastan, MM Gottesman Seminars in cell biology 4 (1), 63-76, 1993 | 196 | 1993 |
Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein (∗) M Müller, É Bakos, E Welker, A Váradi, UA Germann, MM Gottesman, ... Journal of Biological Chemistry 271 (4), 1877-1883, 1996 | 191 | 1996 |
Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance: in vitro UA Germann, D Shlyakhter, VS Mason, RE Zelle, JP Duffy, V Galullo, ... Anti-cancer drugs 8 (2), 125-140, 1997 | 188 | 1997 |
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control AM Aronov, Q Tang, G Martinez-Botella, GW Bemis, J Cao, G Chen, ... Journal of medicinal chemistry 52 (20), 6362-6368, 2009 | 184 | 2009 |
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug … UA Germann, PJ Ford, D Shlyakhter, VS Mason, MW Harding Anti-cancer drugs 8 (2), 141-155, 1997 | 181 | 1997 |
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo Z Shao, K Bhattacharya, E Hsich, L Park, B Walters, U Germann, ... Circulation research 98 (1), 111-118, 2006 | 179 | 2006 |
Both ATP sites of human P-glycoprotein are essential but not symmetric CA Hrycyna, M Ramachandra, UA Germann, PW Cheng, I Pastan, ... Biochemistry 38 (42), 13887-13899, 1999 | 179 | 1999 |
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus UA Germann, MC Willingham, I Pastan, MM Gottesman Biochemistry 29 (9), 2295-2303, 1990 | 159 | 1990 |