gergely szakacs
gergely szakacs
Institute of Enzymology
E-mail megerősítve itt: biomembrane.hu
Cím
Hivatkozott rá
Hivatkozott rá
Év
Targeting multidrug resistance in cancer
G Szakács, JK Paterson, JA Ludwig, C Booth-Genthe, MM Gottesman
Nature reviews Drug discovery 5 (3), 219-234, 2006
31862006
Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
B Sarkadi, L Homolya, G Szakács, A Váradi
Physiological reviews 86 (4), 1179-1236, 2006
7472006
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells
G Szakács, JP Annereau, S Lababidi, U Shankavaram, A Arciello, ...
Cancer cell 6 (2), 129-137, 2004
5642004
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)
G Szakács, A Váradi, C Özvegy-Laczka, B Sarkadi
Drug discovery today 13 (9-10), 379-393, 2008
5022008
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
C Ozvegy, T Litman, G Szakács, Z Nagy, S Bates, A Váradi, B Sarkadi
Biochemical and biophysical research communications 285 (1), 111-117, 2001
3712001
Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain
É Bakos, R Evers, G Szakács, GE Tusnády, E Welker, K Szabó, ...
Journal of Biological Chemistry 273 (48), 32167-32175, 1998
3491998
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping
AJ Smith, A Van Helvoort, G Van Meer, K Szabó, E Welker, G Szakács, ...
Journal of Biological Chemistry 275 (31), 23530-23539, 2000
3062000
Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti‐cancer effects and pharmacological properties
C Hegedűs, C Özvegy‐Laczka, A Apati, M Magocsi, K Nemet, L Őrfi, ...
British journal of pharmacology 158 (4), 1153-1164, 2009
2012009
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer
JA Ludwig, G Szakács, SE Martin, BF Chu, C Cardarelli, ZE Sauna, ...
Cancer research 66 (9), 4808-4815, 2006
1922006
Synthesis, activity, and pharmacophore development for isatin-β-thiosemicarbazones with selective activity toward multidrug-resistant cells
MD Hall, NK Salam, JL Hellawell, HM Fales, CB Kensler, JA Ludwig, ...
Journal of medicinal chemistry 52 (10), 3191-3204, 2009
1562009
The controversial role of ABC transporters in clinical oncology
FJ Sharom, A Tamaki, C Ierano, G Szakacs, RW Robey, SE Bates
Essays in biochemistry 50, 209-232, 2011
1552011
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
M Okabe, G Szakács, MA Reimers, T Suzuki, MD Hall, T Abe, ...
Molecular cancer therapeutics 7 (9), 3081-3091, 2008
1462008
Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance
G Szakács, MD Hall, MM Gottesman, A Boumendjel, R Kachadourian, ...
Chemical reviews 114 (11), 5753-5774, 2014
1362014
Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells
JK Lee, KJ Bussey, FG Gwadry, W Reinhold, G Riddick, SL Pelletier, ...
Genome biology 4 (12), R82, 2003
1302003
Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1)
E Bakos, R Evers, G Calenda, GE Tusnády, G Szakács, A Váradi, ...
Journal of cell science 113 (24), 4451-4461, 2000
1292000
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane
JK Paterson, S Shukla, CM Black, T Tachiwada, S Garfield, S Wincovitch, ...
Biochemistry 46 (33), 9443-9452, 2007
1242007
A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)
SV Ambudkar, ZE Sauna, MM Gottesman, G Szakacs
Trends in pharmacological sciences 26 (8), 385-387, 2005
1012005
Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?
A Brózik, C Hegedüs, Z Erdei, T Hegedűs, C Özvegy-Laczka, G Szakács, ...
Expert opinion on drug metabolism & toxicology 7 (5), 623-642, 2011
992011
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
JP Annereau, G Szakacs, CJ Tucker, A Arciello, C Cardarelli, J Collins, ...
Molecular pharmacology 66 (6), 1397-1405, 2004
992004
Identification of compounds selectively killing multidrug-resistant cancer cells
D Türk, MD Hall, BF Chu, JA Ludwig, HM Fales, MM Gottesman, ...
Cancer research 69 (21), 8293-8301, 2009
972009
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