David I Roper
David I Roper
Professor of Biochemistry & Structural Biology
E-mail megerősítve itt: warwick.ac.uk - Kezdőlap
Hivatkozott rá
Hivatkozott rá
Bacterial cell wall assembly: still an attractive antibacterial target
TDH Bugg, D Braddick, CG Dowson, DI Roper
Trends in biotechnology 29 (4), 167-173, 2011
Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases
HS Subramanya, DI Roper, Z Dauter, EJ Dodson, GJ Davies, KS Wilson, ...
Biochemistry 35 (3), 792-802, 1996
Vancomycin resistance in enterococci: reprogramming of the d-Ala–d-Ala ligases in bacterial peptidoglycan biosynthesis
VL Healy, IAD Lessard, DI Roper, JR Knox, CT Walsh
Chemistry & biology 7 (5), R109-R119, 2000
Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins
TDH Bugg, AJ Lloyd, DI Roper
Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2006
Understanding the mechanism of ice binding by type III antifreeze proteins
AA Antson, DJ Smith, DI Roper, S Lewis, LSD Caves, CS Verma, ...
Journal of molecular biology 305 (4), 875-889, 2001
CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits
L Meigh, SA Greenhalgh, TL Rodgers, MJ Cann, DI Roper, N Dale
Elife 2, e01213, 2013
Asymmetric triplex metallohelices with high and selective activity against cancer cells
AD Faulkner, RA Kaner, QMA Abdallah, G Clarkson, DJ Fox, P Gurnani, ...
Nature Chemistry 6 (9), 797-803, 2014
Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis
E Kuru, A Radkov, X Meng, A Egan, L Alvarez, A Dowson, G Booher, ...
ACS Chemical Biology 14 (12), 2745-2756, 2019
A road map for prioritizing warheads for cysteine targeting covalent inhibitors
P Abranyi-Balogh, L Petri, T Imre, P Szijj, A Scarpino, M Hrast, A Mitrović, ...
European journal of medicinal chemistry 160, 94-107, 2018
FtsZ polymer-bundling by the Escherichia coli ZapA orthologue, YgfE, involves a conformational change in bound GTP
E Small, R Marrington, A Rodger, DJ Scott, K Sloan, D Roper, TR Dafforn, ...
Journal of molecular biology 369 (1), 210-221, 2007
The physico-chemical characterization of a boiling stable antifreeze protein from a perennial grass (Lolium perenne)
PDA Pudney, SL Buckley, CM Sidebottom, SN Twigg, MP Sevilla, CB Holt, ...
Archives of Biochemistry and Biophysics 410 (2), 238-245, 2003
IFN-γ enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2
S Tötemeyer, M Sheppard, A Lloyd, D Roper, C Dowson, D Underhill, ...
The Journal of Immunology 176 (8), 4804-4810, 2006
Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
H Kishida, S Unzai, DI Roper, A Lloyd, SY Park, JRH Tame
Biochemistry 45 (3), 783-792, 2006
In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae
A Zapun, J Philippe, KA Abrahams, L Signor, DI Roper, E Breukink, ...
ACS chemical biology 8 (12), 2688-2696, 2013
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan
AJ Lloyd, AM Gilbey, AM Blewett, G De Pascale, A El Zoeiby, ...
Journal of Biological Chemistry 283 (10), 6402-6417, 2008
Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing
ES Lysenko, TB Clarke, M Shchepetov, AJ Ratner, DI Roper, CG Dowson, ...
PLoS pathogens 3 (8), e118, 2007
The molecular basis of vancomycin resistance in clinically relevant Enterococci: Crystal structure of d-alanyl-d-lactate ligase (VanA)
DI Roper, T Huyton, A Vagin, G Dodson
Proceedings of the National Academy of Sciences 97 (16), 8921-8925, 2000
Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein
ACK Teo, SC Lee, NL Pollock, Z Stroud, S Hall, A Thakker, AR Pitt, ...
Scientific Reports 9 (1), 1813, 2019
The Escherichia coli C homoprotocatechuate degradative operon: hpc gene order, direction of transcription and control of expression
DI Roper, T Fawcett, RA Cooper
Molecular and General Genetics MGG 237, 241-250, 1993
Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a
S Paulin, M Jamshad, TR Dafforn, J Garcia-Lara, SJ Foster, NF Galley, ...
Nanotechnology 25 (28), 285101, 2014
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