| Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage PI Kulcsár, A Tálas, K Huszár, Z Ligeti, E Tóth, N Weinhardt, E Fodor, ... Genome biology 18, 1-17, 2017 | 137 | 2017 |
| Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases E Toth, E Varga, PI Kulcsár, V Kocsis-Jutka, SL Krausz, A Nyeste, ... Nucleic acids research 48 (7), 3722-3733, 2020 | 93 | 2020 |
| Mb-and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants E Tóth, BC Czene, PI Kulcsár, SL Krausz, A Tálas, A Nyeste, É Varga, ... Nucleic acids research 46 (19), 10272-10285, 2018 | 64 | 2018 |
| Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells E Tóth, N Weinhardt, P Bencsura, K Huszár, PI Kulcsár, A Tálas, E Fodor, ... Biology direct 11, 1-14, 2016 | 64 | 2016 |
| Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′ G-extended sgRNAs PI Kulcsár, A Tálas, E Tóth, A Nyeste, Z Ligeti, Z Welker, E Welker Nature communications 11 (1), 1223, 2020 | 39 | 2020 |
| A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a ‘self-cleaving’GFP-expression plasmid A Tálas, PI Kulcsár, N Weinhardt, A Borsy, E Tóth, K Szebenyi, SL Krausz, ... DNA Research 24 (6), 609-621, 2017 | 27 | 2017 |
| PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells DA Simon, A Tálas, PI Kulcsár, Z Biczók, SL Krausz, G Várady, E Welker Elife 11, e69504, 2022 | 25 | 2022 |
| SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e PI Kulcsár, A Tálas, Z Ligeti, SL Krausz, E Welker Nature Communications 13 (1), 6858, 2022 | 24* | 2022 |
| BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors A Tálas, DA Simon, PI Kulcsár, É Varga, SL Krausz, E Welker Nature communications 12 (1), 6353, 2021 | 16 | 2021 |
| A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs A Tálas, K Huszár, PI Kulcsár, JK Varga, É Varga, E Tóth, Z Welker, ... Nucleic Acids Research 49 (6), e31-e31, 2021 | 12 | 2021 |
| Identification of new interactions between endolysosomal tethering factors Z Simon-Vecsei, Á Sőth, P Lőrincz, A Rubics, A Tálas, PI Kulcsár, ... Journal of Molecular Biology 433 (13), 166965, 2021 | 3 | 2021 |
| Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs K Huszár, Z Welker, Z Györgypál, E Tóth, Z Ligeti, PI Kulcsár, J Dancsó, ... Nucleic Acids Research 51 (11), 5847-5863, 2023 | 2 | 2023 |
| Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning N Mathis, A Allam, A Tálas, E Benvenuto, R Schep, T Damodharan, ... bioRxiv, 2023.10. 09.561414, 2023 | 2 | 2023 |
| Treatment of a genetic liver disease in mice through transient prime editor expression T Rothgangl, EI Ioannidi, Y Weber, A Talas, D Boeck, M Matsushita, ... bioRxiv, 2024.01. 22.575834, 2024 | 1 | 2024 |
| A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets PI Kulcsár, A Tálas, Z Ligeti, E Tóth, Z Rakvács, Z Bartos, SL Krausz, ... Nature Communications 14 (1), 5746, 2023 | 1 | 2023 |
| Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects PI Kulcsár, A Tálas, Z Ligeti, E Tóth, Z Rakvács, VL Végi, SL Krausz, ... bioRxiv, 2022.08. 16.504097, 2022 | 1 | 2022 |
| Variant cas9 E Welker, P Kulcsár, A Tálas, T Eszter, Z Ligeti, A Nyeste, Z Welker US Patent App. 17/781,452, 2023 | | 2023 |
