| Skeletal muscle myocytes undergo protein loss and reactive oxygen‐mediated NF‐κB activation in response to tumor necrosis factorα YP Li, RJ Schwartz, ID Waddell, BR Holloway, MB Reid The FASEB Journal 12 (10), 871-880, 1998 | 671 | 1998 |
| TNF‐α increases ubiquitin‐conjugating activity in skeletal muscle by up‐regulating UbcH2/E220k YP Li, SH Lecker, Y Chen, ID Waddell, AL Goldberg, MB Reid The FASEB journal 17 (9), 1048-1057, 2003 | 252 | 2003 |
| Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators KJ Brocklehurst, VA Payne, RA Davies, D Carroll, HL Vertigan, ... Diabetes 53 (3), 535-541, 2004 | 188 | 2004 |
| Proteolysis‐inducing factor regulates hepatic gene expression via the transcription factors NF‐κΒ and STAT3 TM Watchorn, ID Waddell, N Dowidar, JA Ross The FASEB Journal 15 (3), 562-564, 2001 | 128 | 2001 |
| First-in-class chemical probes against poly (ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to olaparib DI James, KM Smith, AM Jordan, EE Fairweather, LA Griffiths, ... ACS chemical biology 11 (11), 3179-3190, 2016 | 127 | 2016 |
| Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia MB Pappalardi, K Keenan, M Cockerill, WA Kellner, A Stowell, C Sherk, ... Nature cancer 2 (10), 1002-1017, 2021 | 118 | 2021 |
| The molecular basis of the hepatic microsomal glucose-6-phosphatase system A Burchell, ID Waddell Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1092 (2), 129-137, 1991 | 106 | 1991 |
| Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments JR Hitchin, J Blagg, R Burke, S Burns, MJ Cockerill, EE Fairweather, ... MedChemComm 4 (11), 1513-1522, 2013 | 79 | 2013 |
| The microsomal glucose-6-phosphatase enzyme of pancreatic islets. ID Waddell, A Burchell Biochemical Journal 255 (2), 471, 1988 | 79 | 1988 |
| Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II A Raoof, P Depledge, NM Hamilton, NS Hamilton, JR Hitchin, GV Hopkins, ... Journal of medicinal chemistry 56 (16), 6352-6370, 2013 | 74 | 2013 |
| The phosphohydrolase component of the hepatic microsomal glucose-6-phosphatase system is a 36.5-kilodalton polypeptide. JL Countaway, ID Waddell, A Burchell, WJ Arion Journal of Biological Chemistry 263 (6), 2673-2678, 1988 | 74 | 1988 |
| Novel steroid inhibitors of glucose 6-phosphate dehydrogenase NM Hamilton, M Dawson, EE Fairweather, NS Hamilton, JR Hitchin, ... Journal of medicinal chemistry 55 (9), 4431-4445, 2012 | 70 | 2012 |
| Leptin and its relation to weight loss, ob gene expression and the acute‐phase response in surgical patients AGW Moses, N Dowidar, B Holloway, I Waddell, KCH Fearon, JA Ross British Journal of Surgery 88 (4), 588-593, 2001 | 70 | 2001 |
| Differential gene expression between Zucker Fatty rats and Zucker Diabetic Fatty rats: a potential role for the immediate-early gene Egr-1 in regulation of beta cell proliferation KE Garnett, P Chapman, JA Chambers, ID Waddell, DSW Boam Journal of molecular endocrinology 35 (1), 13-26, 2005 | 64 | 2005 |
| Identification and characterization of a hepatic microsomal glucose transport protein. T3 of the glucose-6-phosphatase system? ID Waddell, H Scott, A Grant, A Burchell Biochemical journal 275 (2), 363-367, 1991 | 57 | 1991 |
| The ontogeny of human hepatic microsomal glucose-6-phosphatase proteins A Burchell, L Gibb, ID Waddell, M Giles, R Hume Clinical chemistry 36 (9), 1633-1637, 1990 | 54 | 1990 |
| Discovery and optimization of allosteric inhibitors of mutant isocitrate dehydrogenase 1 (R132H IDH1) displaying activity in human acute myeloid leukemia cells S Jones, J Ahmet, K Ayton, M Ball, M Cockerill, E Fairweather, N Hamilton, ... Journal of Medicinal Chemistry 59 (24), 11120-11137, 2016 | 53 | 2016 |
| The identification of T2; the phosphate/pyrophosphate transport protein of the hepatic microsomal glucose‐6‐phosphatase system ID Waddell, JG Lindsay, A Burchell FEBS letters 229 (1), 179-182, 1988 | 51 | 1988 |
| Proteolysis-inducing factor differentially influences transcriptional regulation in endothelial subtypes TM Watchorn, I Waddell, JA Ross American Journal of Physiology-Endocrinology and Metabolism 282 (4), E763-E769, 2002 | 50 | 2002 |
| The cachectic mediator proteolysis inducing factor activates NF-κB and STAT3 in human Kupffer cells and monocytes TM Watchorn, N Dowidar, CHC Dejong, ID Waddell, OJ Garden, JA Ross International journal of oncology 27 (4), 1105-1111, 2005 | 46 | 2005 |
Allan JordanVice President of Oncology Drug Discovery, Sygnature DiscoveryE-mail megerősítve itt: thejordans.org.uk
