Követés
Toshimasa Itoh
Toshimasa Itoh
Showa Pharmaceutical University
E-mail megerősítve itt: ac.shoyaku.ac.jp
Cím
Hivatkozott rá
Hivatkozott rá
Év
Structural basis for the activation of PPARγ by oxidized fatty acids
T Itoh, L Fairall, K Amin, Y Inaba, A Szanto, BL Balint, L Nagy, ...
Nature structural & molecular biology 15 (9), 924-931, 2008
5102008
4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor γ agonist alleviates the symptoms of DSS-induced colitis
K Yamamoto, Y Ninomiya, M Iseki, Y Nakachi, Y Kanesaki-Yatsuka, ...
Biochemical and Biophysical Research Communications 367 (3), 566-572, 2008
1602008
Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents
K Yamamoto, T Itoh, D Abe, M Shimizu, T Kanda, T Koyama, M Nishikawa, ...
Bioorganic & medicinal chemistry letters 15 (3), 517-522, 2005
982005
Selective inhibition of methoxyflavonoids on human CYP1B1 activity
H Takemura, T Itoh, K Yamamoto, H Sakakibara, K Shimoi
Bioorganic & medicinal chemistry 18 (17), 6310-6315, 2010
912010
asymmetric synthesis of (−)-adaline
T Itoh, N Yamazaki, C Kibayashi
Organic Letters 4 (15), 2469-2472, 2002
802002
Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis
M Choi, K Yamamoto, T Itoh, M Makishima, DJ Mangelsdorf, D Moras, ...
Chemistry & biology 10 (3), 261-270, 2003
712003
Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand
T Itoh, K Yamamoto
Naunyn-Schmiedeberg's archives of pharmacology 377, 541-547, 2008
682008
Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents
T Itoh, I Murota, K Yoshikai, S Yamada, K Yamamoto
Bioorganic & medicinal chemistry 14 (1), 98-108, 2006
662006
Asymmetric Synthesis of (−)-Indolizidines 167B and 209D Based on Stereocontrolled Allylation of a Chiral Tricyclic N-Acyl-N,O-acetal
N Yamazaki, T Ito, C Kibayashi
Organic Letters 2 (4), 465-467, 2000
652000
Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting
T Itoh, L Fairall, FW Muskett, CP Milano, PJ Watson, N Arnaudo, A Saleh, ...
Nucleic Acids Research 43 (4), 2033-2044, 2015
622015
Total synthesis of the coccinellid alkaloid (−)-adalinine and the assignment of its absolute configuration
N Yamazaki, T Ito, C Kibayashi
Tetrahedron letters 40 (4), 739-742, 1999
571999
Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls
H Inui, T Itoh, K Yamamoto, SI Ikushiro, T Sakaki
International journal of molecular sciences 15 (8), 14044-14057, 2014
532014
Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3, 3′, 4, 4′, 5-pentachlorobiphenyl
K Yamazaki, M Suzuki, T Itoh, K Yamamoto, M Kanemitsu, C Matsumura, ...
The journal of biochemistry 149 (4), 487-494, 2011
532011
Biomimetic Total Synthesis of (±)-8-Oxoerymelanthine
Y Yoshida, K Mohri, K Isobe, T Itoh, K Yamamoto
The Journal of Organic Chemistry 74 (16), 6010-6015, 2009
502009
A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22 R …
Y Anami, T Itoh, D Egawa, N Yoshimoto, K Yamamoto
Journal of medicinal chemistry 57 (10), 4351-4367, 2014
452014
A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol
T Itoh, H Takemura, K Shimoi, K Yamamoto
Journal of chemical information and modeling 50 (6), 1173-1178, 2010
422010
PPARα ligand-binding domain structures with endogenous fatty acids and fibrates
S Kamata, T Oyama, K Saito, A Honda, Y Yamamoto, K Suda, R Ishikawa, ...
Iscience 23 (11), 2020
412020
17-OxoDHA is a PPARα/γ dual covalent modifier and agonist
D Egawa, T Itoh, Y Akiyama, T Saito, K Yamamoto
ACS Chemical Biology 11 (9), 2447-2455, 2016
362016
Apo-and antagonist-binding structures of vitamin D receptor ligand-binding domain revealed by hybrid approach combining small-angle X-ray scattering and molecular dynamics
Y Anami, N Shimizu, T Ekimoto, D Egawa, T Itoh, M Ikeguchi, ...
Journal of Medicinal Chemistry 59 (17), 7888-7900, 2016
352016
Substitution at carbon 2 of 19-nor-1α, 25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells
D Iglesias-Gato, S Zheng, JN Flanagan, L Jiang, A Kittaka, T Sakaki, ...
The Journal of steroid biochemistry and molecular biology 127 (3-5), 269-275, 2011
352011
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