Andrew Doig
Andrew Doig
Professor of Biochemistry, University of Manchester
E-mail megerősítve itt: manchester.ac.uk
Hivatkozott rá
Hivatkozott rá
Drug repurposing: progress, challenges and recommendations
S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ...
Nature reviews Drug discovery 18 (1), 41-58, 2019
Distinguishing enzyme structures from non-enzymes without alignments
PD Dobson, AJ Doig
Journal of molecular biology 330 (4), 771-783, 2003
Amyloid β protein and Alzheimer’s disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone, O Berthoumieu, NV Buchete, ...
Chemical reviews 115 (9), 3518-3563, 2015
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer’s disease, Parkinson’s disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo, J Zheng, P Faller, JE Straub, ...
Chemical reviews 121 (4), 2545-2647, 2021
N‐and C‐capping preferences for all 20 amino acids in α‐helical peptides
AJ Doig, RL Baldwin
Protein Science 4 (7), 1325-1336, 1995
Side‐chain conformational entropy in protein folding
AJ Doig, MJE Sternberg
Protein Science 4 (11), 2247-2251, 1995
Properties and identification of human protein drug targets
TM Bakheet, AJ Doig
Bioinformatics 25 (4), 451-457, 2009
Inhibition of toxicity in the β-amyloid peptide fragment β-(25–35) using N-methylated derivatives: a general strategy to prevent amyloid formation
E Hughes, RM Burke, AJ Doig
Journal of Biological Chemistry 275 (33), 25109-25115, 2000
Helix capping propensities in peptides parallel those in proteins.
A Chakrabartty, AJ Doig, RL Baldwin
Proceedings of the National Academy of Sciences 90 (23), 11332-11336, 1993
Inhibition of protein aggregation and amyloid formation by small molecules
AJ Doig, P Derreumaux
Current opinion in structural biology 30, 50-56, 2015
Toward the semiquantitative estimation of binding constants. Guides for peptide-peptide binding in aqueous solution
DH Williams, JPL Cox, AJ Doig, M Gardner, U Gerhard, PT Kaye, AR Lal, ...
Journal of the American Chemical Society 113 (18), 7020-7030, 1991
Is polyproline II helix the killer conformation? A Raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme
EW Blanch, LA Morozova-Roche, DAE Cochran, AJ Doig, L Hecht, ...
Journal of Molecular Biology 301 (2), 553-563, 2000
Is the hydrophobic effect stabilizing or destabilizing in proteins?: The contribution of disulphide bonds to protein stability
AJ Doig, DH Williams
Journal of molecular biology 217 (2), 389-398, 1991
N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure
N Kokkoni, K Stott, H Amijee, JM Mason, AJ Doig
Biochemistry 45 (32), 9906-9918, 2006
Determination of free energies of N-Capping in. alpha.-helixes by modification of the Lifson-Roig Helix-Coil theory to include N-and C-Capping
AJ Doig, A Chakrabartty, TM Klingler, RL Baldwin
Biochemistry 33 (11), 3396-3403, 1994
Predicting enzyme class from protein structure without alignments
PD Dobson, AJ Doig
Journal of molecular biology 345 (1), 187-199, 2005
Why is research on amyloid-β failing to give new drugs for Alzheimer’s disease?
AJ Doig, MP del Castillo-Frias, O Berthoumieu, B Tarus, ...
ACS chemical neuroscience 8 (7), 1435-1437, 2017
Design strategies for anti-amyloid agents
JM Mason, N Kokkoni, K Stott, AJ Doig
Current opinion in structural biology 13 (4), 526-532, 2003
Properties of protein drug target classes
SC Bull, AJ Doig
PloS one 10 (3), e0117955, 2015
Effect of phosphorylation on α-helix stability as a function of position
CD Andrew, J Warwicker, GR Jones, AJ Doig
Biochemistry 41 (6), 1897-1905, 2002
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