The many faces of FKBP51 A Hähle, S Merz, C Meyners, F Hausch Biomolecules 9 (1), 35, 2019 | 99 | 2019 |
The enzyme activity of histone deacetylase 8 is modulated by a redox-switch N Jänsch, C Meyners, M Muth, A Kopranovic, O Witt, I Oehme, ... Redox Biology 20, 60-67, 2019 | 36 | 2019 |
Structure-based design of high-affinity macrocyclic FKBP51 inhibitors M Bauder, C Meyners, PL Purder, S Merz, WO Sugiarto, AM Voll, ... Journal of medicinal chemistry 64 (6), 3320-3349, 2021 | 35 | 2021 |
Potent and selective non‐hydroxamate histone deacetylase 8 inhibitors A Kleinschek, C Meyners, E Digiorgio, C Brancolini, FJ Meyer‐Almes ChemMedChem 11 (23), 2598-2606, 2016 | 30 | 2016 |
A Fluorescence‐Lifetime‐Based Binding Assay for Class IIa Histone Deacetylases C Meyners, M Mertens, P Wessig, FJ Meyer‐Almes Chemistry–A European Journal 23 (13), 3107-3116, 2017 | 27 | 2017 |
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3. 1] aza-amides JM Kolos, S Pomplun, S Jung, B Rieß, PL Purder, AM Voll, S Merz, ... Chemical science 12 (44), 14758-14765, 2021 | 23 | 2021 |
A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5-f][1,3]benzodioxole … C Meyners, R Wawrzinek, A Krämer, S Hinz, P Wessig, FJ Meyer-Almes Analytical and bioanalytical chemistry 406, 4889-4897, 2014 | 23 | 2014 |
Macrocyclic FKBP51 ligands define a transient binding mode with enhanced selectivity AM Voll, C Meyners, MC Taubert, T Bajaj, T Heymann, S Merz, ... Angewandte Chemie International Edition 60 (24), 13257-13263, 2021 | 22 | 2021 |
Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors C Meyners, MGJ Baud, MJ Fuchter, FJ Meyer-Almes Analytical biochemistry 460, 39-46, 2014 | 20 | 2014 |
Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145 S Krysenko, A Matthews, N Okoniewski, A Kulik, MG Girbas, O Tsypik, ... MBio 10 (3), 10.1128/mbio. 00326-19, 2019 | 17 | 2019 |
Cover Feature: Enantioselective Synthesis of a Tricyclic, sp3‐Rich Diazatetradecanedione: an Amino Acid‐Based Natural Product‐Like Scaffold (Chem. Eur. J. 21 … M Bischoff, P Mayer, C Meyners, F Hausch Chemistry-A European Journal 26 (21), 2020 | 10* | 2020 |
FKBP51 and FKBP12. 6—Novel and tight interactors of Glomulin A Hähle, TM Geiger, S Merz, C Meyners, M Tianqi, J Kolos, F Hausch PLoS One 14 (9), e0221926, 2019 | 9 | 2019 |
Features of the transglutaminase-activating metalloprotease from Streptomyces mobaraensis DSM 40847 produced in Escherichia coli NE Juettner, M Classen, F Colin, SB Hoffmann, C Meyners, F Pfeifer, ... Journal of biotechnology 281, 115-122, 2018 | 9 | 2018 |
Structure-based discovery of a new selectivity-enabling motif for the FK506-binding protein 51 FH Knaup, C Meyners, WO Sugiarto, S Wedel, M Springer, C Walz, ... Journal of medicinal chemistry 66 (8), 5965-5980, 2023 | 8 | 2023 |
Fenton-chemistry-based oxidative modification of proteins reflects their conformation T Nehls, T Heymann, C Meyners, F Hausch, F Lermyte International journal of molecular sciences 22 (18), 9927, 2021 | 8 | 2021 |
Destructive twisting of neutral metalloproteases: the catalysis mechanism of the Dispase autolysis‐inducing protein from Streptomyces mobaraensis DSM 40487 D Fiebig, J Storka, M Roeder, C Meyners, S Schmelz, W Blankenfeldt, ... The FEBS Journal 285 (22), 4246-4264, 2018 | 8 | 2018 |
Binding pocket stabilization by high-throughput screening of yeast display libraries JA Lerma Romero, C Meyners, A Christmann, LM Reinbold, ... Frontiers in Molecular Biosciences 9, 1023131, 2022 | 7* | 2022 |
Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes C Meyners, MGJ Baud, MJ Fuchter, FJ Meyer‐Almes Journal of Molecular Recognition 27 (3), 160-172, 2014 | 7 | 2014 |
Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa C Meyners, B Wolff, A Kleinschek, A Krämer, FJ Meyer-Almes Bioorganic & medicinal chemistry letters 27 (7), 1508-1512, 2017 | 6 | 2017 |
The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket C Meyners, A Krämer, Ö Yildiz, FJ Meyer-Almes Biochimica et Biophysica Acta (BBA)-General Subjects 1861 (7), 1855-1863, 2017 | 5 | 2017 |