Andreas C. Joerger
Andreas C. Joerger
Structural Genomics Consortium (SGC), Institute of Pharmaceutical Chemistry, Goethe University
E-mail megerősítve itt: pharmchem.uni-frankfurt.de
Hivatkozott rá
Hivatkozott rá
Principles and applications of halogen bonding in medicinal chemistry and chemical biology
R Wilcken, MO Zimmermann, A Lange, AC Joerger, FM Boeckler
Journal of medicinal chemistry 56 (4), 1363-1388, 2013
Structural biology of the tumor suppressor p53
AC Joerger, AR Fersht
Annu. Rev. Biochem. 77, 557-582, 2008
The p53 pathway: origins, inactivation in cancer, and emerging therapeutic approaches
AC Joerger, AR Fersht
Annual review of biochemistry 85, 375-404, 2016
Structure–function–rescue: the diverse nature of common p53 cancer mutants
AC Joerger, AR Fersht
Oncogene 26 (15), 2226-2242, 2007
The tumor suppressor p53: from structures to drug discovery
AC Joerger, AR Fersht
Cold Spring Harbor perspectives in biology 2 (6), a000919, 2010
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
FM Boeckler, AC Joerger, G Jaggi, TJ Rutherford, DB Veprintsev, ...
Proceedings of the National Academy of Sciences 105 (30), 10360-10365, 2008
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs
AC Joerger, HC Ang, AR Fersht
Proceedings of the National Academy of Sciences 103 (41), 15056-15061, 2006
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
VN Uversky, V Davé, LM Iakoucheva, P Malaney, SJ Metallo, RR Pathak, ...
Chemical reviews 114 (13), 6844-6879, 2014
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53
R Wilcken, X Liu, MO Zimmermann, TJ Rutherford, AR Fersht, AC Joerger, ...
Journal of the American Chemical Society 134 (15), 6810-6818, 2012
Small molecule induced reactivation of mutant p53 in cancer cells
X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, ...
Nucleic acids research 41 (12), 6034-6044, 2013
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations
AC Joerger, HC Ang, DB Veprintsev, CM Blair, AR Fersht
Journal of Biological Chemistry 280 (16), 16030-16037, 2005
Crystal structure of a superstable mutant of human p53 core domain: insights into the mechanism of rescuing oncogenic mutations
AC Joerger, MD Allen, AR Fersht
Journal of Biological Chemistry 279 (2), 1291-1296, 2004
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains
HC Ang, AC Joerger, S Mayer, AR Fersht
Journal of Biological Chemistry 281 (31), 21934-21941, 2006
Structural evolution of p53, p63, and p73: implication for heterotetramer formation
AC Joerger, S Rajagopalan, E Natan, DB Veprintsev, CV Robinson, ...
Proceedings of the National Academy of Sciences 106 (42), 17705-17710, 2009
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant
N Basse, JL Kaar, G Settanni, AC Joerger, TJ Rutherford, AR Fersht
Chemistry & biology 17 (1), 46-56, 2010
Structural biology of the tumor suppressor p53 and cancer‐associated mutants
AC Joerger, AR Fersht
Advances in cancer research 97, 1-23, 2007
Design of a molecular support for cryo-EM structure determination
TG Martin, TAM Bharat, AC Joerger, X Bai, F Praetorius, AR Fersht, ...
Proceedings of the National Academy of Sciences 113 (47), E7456-E7463, 2016
Correlation of levels of folded recombinant p53 in Escherichia coli with thermodynamic stability in vitro
S Mayer, S Rüdiger, HC Ang, AC Joerger, AR Fersht
Journal of molecular biology 372 (1), 268-276, 2007
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer
E Natan, C Baloglu, K Pagel, SMV Freund, N Morgner, CV Robinson, ...
Journal of molecular biology 409 (3), 358-368, 2011
Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity
AC Joerger, S Mayer, AR Fersht
Proceedings of the National Academy of Sciences 100 (10), 5694-5699, 2003
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