Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering DL Stassi, SJ Kakavas, KA Reynolds, G Gunawardana, S Swanson, ... Proceedings of the National Academy of Sciences 95 (13), 7305-7309, 1998 | 228 | 1998 |
Antibacterial targets in fatty acid biosynthesis HT Wright, KA Reynolds Current opinion in microbiology 10 (5), 447-453, 2007 | 218 | 2007 |
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine AS Eustáquio, RP McGlinchey, Y Liu, C Hazzard, LL Beer, G Florova, ... Proceedings of the National Academy of Sciences 106 (30), 12295-12300, 2009 | 196 | 2009 |
Antimalarial activity of natural and synthetic prodiginines K Papireddy, M Smilkstein, JX Kelly, Shweta, SM Salem, M Alhamadsheh, ... Journal of medicinal chemistry 54 (15), 5296-5306, 2011 | 167 | 2011 |
Crystal Structure of the Mycobacterium tuberculosisβ-Ketoacyl-Acyl Carrier Protein Synthase III JN Scarsdale, G Kazanina, X He, KA Reynolds, HT Wright Journal of Biological Chemistry 276 (23), 20516-20522, 2001 | 160 | 2001 |
Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae YJ Yoon, BJ Beck, BS Kim, HY Kang, KA Reynolds, DH Sherman Chemistry & biology 9 (2), 203-214, 2002 | 150 | 2002 |
Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae DJ Wilson, Y Xue, KA Reynolds, DH Sherman Journal of bacteriology 183 (11), 3468-3475, 2001 | 147 | 2001 |
Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin BS Kim, TA Cropp, BJ Beck, DH Sherman, KA Reynolds Journal of Biological Chemistry 277 (50), 48028-48034, 2002 | 141 | 2002 |
Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin TA Cropp, DJ Wilson, KA Reynolds Nature biotechnology 18 (9), 980-983, 2000 | 131 | 2000 |
Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis L Han, S Lobo, KA Reynolds Journal of bacteriology 180 (17), 4481-4486, 1998 | 130 | 1998 |
Biosynthesis of ansatrienin (mycotrienin) and naphthomycin: Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892 S Chen, D von Bamberg, V Hale, M Breuer, B Hardt, R Müller, HG Floss, ... European journal of biochemistry 261 (1), 98-107, 1999 | 117 | 1999 |
1, 2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH) X He, AME Reeve, UR Desai, GE Kellogg, KA Reynolds Antimicrobial agents and chemotherapy 48 (8), 3093-3102, 2004 | 116 | 2004 |
Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis SJ Mo, PK Sydor, C Corre, MM Alhamadsheh, AE Stanley, SW Haynes, ... Chemistry & biology 15 (2), 137-148, 2008 | 115 | 2008 |
Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains TJ Buchholz, TW Geders, FE Bartley III, KA Reynolds, JL Smith, ... ACS chemical biology 4 (1), 41-52, 2009 | 114 | 2009 |
The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII ST Prigge, X He, L Gerena, NC Waters, KA Reynolds Biochemistry 42 (4), 1160-1169, 2003 | 106 | 2003 |
Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH) Y Li, G Florova, KA Reynolds Journal of bacteriology 187 (11), 3795-3799, 2005 | 101 | 2005 |
Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety BS Moore, H Cho, R Casati, E Kennedy, KA Reynolds, U Mocek, ... Journal of the American Chemical Society 115 (12), 5254-5266, 1993 | 99 | 1993 |
Distinct tRNA accommodation intermediates observed on the ribosome with the antibiotics hygromycin A and A201A YS Polikanov, AL Starosta, MF Juette, RB Altman, DS Terry, W Lu, ... Molecular cell 58 (5), 832-844, 2015 | 92 | 2015 |
Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster N Palaniappan, BS Kim, Y Sekiyama, H Osada, KA Reynolds Journal of Biological Chemistry 278 (37), 35552-35557, 2003 | 86 | 2003 |
Purification, Characterization, and Identification of Novel Inhibitors of the β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) from Staphylococcus aureus X He, KA Reynolds Antimicrobial agents and chemotherapy 46 (5), 1310-1318, 2002 | 84 | 2002 |