Evan C. Lien
Evan C. Lien
Assistant Professor, Van Andel Institute
E-mail megerősítve itt: vai.org
Hivatkozott rá
Hivatkozott rá
PI3K signaling in cancer: beyond AKT
EC Lien, CC Dibble, A Toker
Current opinion in cell biology 45, 62-71, 2017
Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton
H Hu, A Juvekar, CA Lyssiotis, EC Lien, JG Albeck, D Oh, G Varma, ...
Cell 164 (3), 433-446, 2016
Glutathione biosynthesis is a metabolic vulnerability in PI (3) K/Akt-driven breast cancer
EC Lien, CA Lyssiotis, A Juvekar, H Hu, JM Asara, LC Cantley, A Toker
Nature cell biology 18 (5), 572-578, 2016
Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer
EC Lien, CA Lyssiotis, LC Cantley
Metabolism in Cancer, 39-72, 2016
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
AG Cox, KL Hwang, KK Brown, KJ Evason, S Beltz, A Tsomides, ...
Nature cell biology 18 (8), 886-896, 2016
MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis
BG Cuiffo, A Campagne, GW Bell, A Lembo, F Orso, EC Lien, MK Bhasin, ...
Cell stem cell 15 (6), 762-774, 2014
Low glycaemic diets alter lipid metabolism to influence tumour growth
EC Lien, AM Westermark, Y Zhang, C Yuan, Z Li, AN Lau, KM Sapp, ...
Nature 599 (7884), 302-307, 2021
Altered exocrine function can drive adipose wasting in early pancreatic cancer
LV Danai, A Babic, MH Rosenthal, EA Dennstedt, A Muir, EC Lien, ...
Nature 558 (7711), 600-604, 2018
A framework for examining how diet impacts tumour metabolism
EC Lien, MG Vander Heiden
Nature Reviews Cancer 19 (11), 651-661, 2019
Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt
J Zhang, K Xu, P Liu, Y Geng, B Wang, W Gan, J Guo, F Wu, YR Chin, ...
Molecular cell 62 (6), 929-942, 2016
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion
A Juvekar, H Hu, S Yadegarynia, CA Lyssiotis, S Ullas, EC Lien, ...
Proceedings of the National Academy of Sciences 113 (30), E4338-E4347, 2016
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
AG Cox, A Tsomides, D Yimlamai, KL Hwang, J Miesfeld, GG Galli, ...
The EMBO journal 37 (22), e100294, 2018
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
EC Lien, L Ghisolfi, RC Geck, JM Asara, A Toker
Science signaling 10 (510), eaao6604, 2017
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
AN Lau, Z Li, LV Danai, AM Westermark, AM Darnell, R Ferreira, ...
Elife 9, e56782, 2020
Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis
AG Cox, A Tsomides, AJ Kim, D Saunders, KL Hwang, KJ Evason, ...
Proceedings of the National Academy of Sciences 113 (38), E5562-E5571, 2016
The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis
K Shimizu, H Fukushima, K Ogura, EC Lien, NT Nihira, J Zhang, BJ North, ...
Science signaling 10 (460), eaah4117, 2017
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks
N Chatterjee, MA Whitman, CA Harris, SM Min, O Jonas, EC Lien, ...
Proceedings of the National Academy of Sciences 117 (46), 28918-28921, 2020
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Z Li, BW Ji, PD Dixit, EC Lien, K Tchourine, AM Hosios, KL Abbott, ...
bioRxiv, 2020
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression
V Gouirand, T Gicquel, EC Lien, E Jaune‐Pons, Q Da Costa, P Finetti, ...
The EMBO Journal 41 (9), e110466, 2022
Oncogenic AKT1 (E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis
ML Mancini, EC Lien, A Toker
Oncotarget 7 (14), 17301, 2016
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Cikkek 1–20