Challenges in enzyme mechanism and energetics DA Kraut, KS Carroll, D Herschlag Annual review of biochemistry 72 (1), 517-571, 2003 | 328 | 2003 |
Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole DA Kraut, PA Sigala, B Pybus, CW Liu, D Ringe, GA Petsko, D Herschlag PLoS biology 4 (4), e99, 2006 | 152 | 2006 |
Disordered proteinaceous machines M Fuxreiter, A Tóth-Petróczy, DA Kraut, AT Matouschek, RYH Lim, B Xue, ... Chemical reviews 114 (13), 6806-6843, 2014 | 124 | 2014 |
Testing geometrical discrimination within an enzyme active site: Constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole PA Sigala, DA Kraut, JMM Caaveiro, B Pybus, EA Ruben, D Ringe, ... Journal of the American Chemical Society 130 (41), 13696-13708, 2008 | 105 | 2008 |
ATP-dependent proteases differ substantially in their ability to unfold globular proteins P Koodathingal, NE Jaffe, DA Kraut, S Prakash, S Fishbain, C Herman, ... Journal of biological chemistry 284 (28), 18674-18684, 2009 | 85 | 2009 |
Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase JP Schwans, DA Kraut, D Herschlag Proceedings of the National Academy of Sciences 106 (34), 14271-14275, 2009 | 68 | 2009 |
Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole DA Kraut, PA Sigala, TD Fenn, D Herschlag Proceedings of the National Academy of Sciences 107 (5), 1960, 2010 | 65 | 2010 |
Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis DA Kraut, MJ Churchill, PE Dawson, D Herschlag ACS chemical biology 4 (4), 269-273, 2009 | 60 | 2009 |
Sequence-and species-dependence of proteasomal processivity DA Kraut, E Israeli, EK Schrader, A Patil, K Nakai, D Nanavati, T Inobe, ... ACS chemical biology 7 (8), 1444-1453, 2012 | 53 | 2012 |
Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride D Kraut, H Goff, RK Pai, NA Hosea, I Silman, JL Sussman, P Taylor, ... Molecular pharmacology 57 (6), 1243, 2000 | 53 | 2000 |
Substrate ubiquitination controls the unfolding ability of the proteasome EL Reichard, GG Chirico, WJ Dewey, ND Nassif, KE Bard, NE Millas, ... Journal of Biological Chemistry 291 (35), 18547-18561, 2016 | 35 | 2016 |
To degrade or release: ubiquitin-chain remodeling DA Kraut, S Prakash, A Matouschek Trends in cell biology 17 (9), 419-421, 2007 | 35 | 2007 |
Proteasomal Degradation from Internal Sites Favors Partial Proteolysis via Remote Domain Stabilization DA Kraut, A Matouschek ACS chemical biology 6 (10), 1087-1095, 2011 | 34 | 2011 |
Slipping up: Partial substrate degradation by ATP‐dependent proteases ND Nassif, SE Cambray, DA Kraut IUBMB life 66 (5), 309-317, 2014 | 27 | 2014 |
Ubiquitin receptors are required for substrate-mediated activation of the proteasome’s unfolding ability MD Cundiff, CM Hurley, JD Wong, JA Boscia iV, A Bashyal, J Rosenberg, ... Scientific Reports 9 (1), 14506, 2019 | 25 | 2019 |
An integrated computational and experimental approach to identifying inhibitors for SARS-CoV-2 3CL protease T Zhai, F Zhang, S Haider, D Kraut, Z Huang Frontiers in Molecular Biosciences 8, 661424, 2021 | 20 | 2021 |
Mode of targeting to the proteasome determines GFP fate CE Bragança, DA Kraut Journal of Biological Chemistry 295 (47), 15892-15901, 2020 | 19 | 2020 |
Slippery substrates impair ATP-dependent protease function by slowing unfolding DA Kraut Journal of Biological Chemistry 288 (48), 34729-34735, 2013 | 19 | 2013 |
Pup grows up: in vitro characterization of the degradation of pupylated proteins DA Kraut, A Matouschek The EMBO journal 29 (7), 1163-1164, 2010 | 9 | 2010 |
Proteasomal conformation controls unfolding ability JR Cresti, AJ Manfredonia, CE Bragança, JA Boscia IV, CM Hurley, ... Proceedings of the National Academy of Sciences 118 (25), e2101004118, 2021 | 8 | 2021 |