Hit and lead criteria in drug discovery for infectious diseases of the developing world K Katsuno, JN Burrows, K Duncan, RH Van Huijsduijnen, T Kaneko, ... Nature Reviews drug discovery 14 (11), 751-758, 2015 | 572 | 2015 |
Design of orally active, non-peptidic inhibitors of human leukocyte elastase FJ Brown, DW Andisik, PR Bernstein, CB Bryant, C Ceccarelli, ... Journal of medicinal chemistry 37 (9), 1259-1261, 1994 | 119 | 1994 |
Heterocyclic ketones PR Bernstein, A Shaw, RM Thomas, CA Veale, P Warner, DJ Wolanin US Patent 5,721,222, 1998 | 103 | 1998 |
Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors P Warner, RC Green, B Gomes, AM Strimpler Journal of medicinal chemistry 37 (19), 3090-3099, 1994 | 89 | 1994 |
The asymmetric synthesis of β-lactams: Stereocontrolled Asymmetric Tandem Michael Additions and Subsequent Alkylations of E-[(η5-C5H5) Fe (CO)(PPH3) COCH= CHME]. X-ray Crystal … SG Davies, IM Dordor-Hedgecock, KH Sutton, JC Walker, RH Jones, ... Tetrahedron 42 (18), 5123-5137, 1986 | 75 | 1986 |
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate S Hameed P, S Solapure, V Patil, PP Henrich, PA Magistrado, S Bharath, ... Nature Communications 6 (1), 6715, 2015 | 68 | 2015 |
Chiral propionate enolate equivalents for the stereoselective synthesis of threo-or erytho-α,-methyl-β-hydroxy acids SG Davies, IM Dordor-Hedgecock, P Warner Tetrahedron letters 26 (17), 2125-2128, 1985 | 68 | 1985 |
Nonpeptidic Inhibitors of Human Leukocyte Elastase. 2. Design, Synthesis, and in vitro Activity of a Series of 3-Amino-6-aryl-2-oxopyridyl Trifluoromethyl Ketones JR Damewood Jr, PD Edwards, S Feeney, BC Gomes, GB Steelman, ... Journal of medicinal chemistry 37 (20), 3303-3312, 1994 | 64 | 1994 |
1-pyrimidinylacetamide human leukocyte elastate inhibitors PR Bernstein, PD Edwards, A Shaw, RM Thomas, CA Veale, P Warner, ... US Patent 5,441,960, 1995 | 54 | 1995 |
Disubstituted vinylidene complexes of iron and ruthenium: nucleophilic properties of ν1-acetylide ligands S Abbott, SG Davies, P Warner Journal of Organometallic Chemistry 246 (2), c65-c68, 1983 | 49 | 1983 |
Improved stereochemical control and mechanistic aspects of the alkylation of enolates derived from [(η5-C5H5) Fe (CO)(PPh3) COCH2R] SL Brown, SG Davies, DF Foster, JI Seeman, P Warner Tetrahedron letters 27 (5), 623-626, 1986 | 43 | 1986 |
Aromatic amino ethers as pain relieving agents GA Breault, H Tucker, J Oldfield, P Warner US Patent 5,843,942, 1998 | 35 | 1998 |
Stereoselective synthesis of erythro-β-hydroxy carboxylic acids via iron acyl complexes SG Davies, IM Dordor, JC Walker, P Warner Tetrahedron letters 25 (25), 2709-2712, 1984 | 34 | 1984 |
Ortho substituted aromatic compounds useful as antagonists of the pain enhancing effects of E-type prostaglandins GA Breault, J Oldfield, H Tucker, P Warner US Patent 5,811,459, 1998 | 30 | 1998 |
Heterocyclic amides PR Bernstein, A Shaw, RM Thomas, P Warner, DJ Wolanin US Patent 5,521,179, 1996 | 29 | 1996 |
Asymmetric synthesis of 2, 4-disubstituted butyrolactones using the iron chiral auxiliary [(η5-C5H5) Fe (CO)(PPh3)] SG Davies, R Polywka, P Wamer Tetrahedron 46 (13-14), 4847-4856, 1990 | 28 | 1990 |
Synthesis and Characterisation of E and Z α, β-Unsaturated Acyl Complexes [(η5-C5H5) Fe (CO)(PPh3)(COCH= CHR)](R= H, Me, Et, n-Bu, t-Bu, Ph, vinyl, 2-furyl) SG Davies, RJC Easton, JC Walker, P Warner Tetrahedron 42 (1), 175-188, 1986 | 26 | 1986 |
Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists GA Breault, J Oldfield, H Tucker, P Warner US Patent 5,834,468, 1998 | 25 | 1998 |
Chiral discrimination in the reactions of the enolate E-[(η5-C5H5) Fe (CO)(PPh3) COCHMe]− Li+ with cis and trans but-2-ene oxides in the presence of BF3· OEt3 SG Davies, P Warner Tetrahedron letters 26 (39), 4815-4818, 1985 | 25 | 1985 |
Template-directed intramolecular C-glycosidation. Total synthesis of 2, 3-dideoxy-d-manno-2-octulopyranosonic acid D Craig, MW Pennington, P Warner Tetrahedron letters 36 (32), 5815-5818, 1995 | 22 | 1995 |