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Judit Toth
Judit Toth
PI, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences
Verified email at ttk.mta.hu
Title
Cited by
Cited by
Year
Mechanism of blebbistatin inhibition of myosin II
M Kovács, J Tóth, C Hetényi, A Málnási-Csizmadia, JR Sellers
Journal of Biological Chemistry 279 (34), 35557-35563, 2004
10402004
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases
BG Vértessy, J Tóth
Accounts of chemical research 42 (1), 97-106, 2009
2522009
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme
J Tóth, B Varga, M Kovács, A Málnási-Csizmadia, BG Vértessy
Journal of Biological Chemistry 282 (46), 33572-33582, 2007
882007
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase
B Varga, O Barabás, J Kovári, J Tóth, É Hunyadi-Gulyás, É Klement, ...
FEBS letters 581 (24), 4783-4788, 2007
812007
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
I Pecsi, I Leveles, V Harmat, BG Vertessy, J Toth
Nucleic acids research 38 (20), 7179-7186, 2010
652010
The dUTPase enzyme is essential in Mycobacterium smegmatis
I Pecsi, R Hirmondo, AC Brown, A Lopata, T Parish, BG Vertessy, J Tóth
PloS one 7 (5), e37461, 2012
612012
Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family
J Tóth, M Kovács, F Wang, L Nyitray, JR Sellers
Journal of Biological Chemistry 280 (34), 30594-30603, 2005
592005
Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control
JE Szabó, V Németh, V Papp-Kádár, K Nyíri, I Leveles, ÁÁ Bendes, ...
Nucleic acids research 42 (19), 11912-11920, 2014
512014
Switch 1 mutation S217A converts myosin V into a low duty ratio motor
E Forgacs, T Sakamoto, S Cartwright, B Belknap, M Kovács, J Tóth, ...
Journal of Biological Chemistry 284 (4), 2138-2149, 2009
472009
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination
I Pécsi, JE Szabó, SD Adams, I Simon, JR Sellers, BG Vértessy, J Tóth
Proceedings of the National Academy of Sciences 108 (35), 14437-14442, 2011
442011
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
P Erdélyi, É Borsos, K Takács-Vellai, T Kovács, AL Kovács, T Sigmond, ...
Journal of cell science 124 (9), 1510-1518, 2011
442011
Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool,(–)‐Blebbistatin
C Lucas‐Lopez, S Patterson, T Blum, AF Straight, J Toth, AMZ Slawin, ...
European journal of organic chemistry 2005 (9), 1736-1740, 2005
412005
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
G Rona, M Marfori, M Borsos, I Scheer, E Takács, J Toth, F Babos, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2495-2505, 2013
382013
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism
G Merényi, J Kovári, J Tóth, E Takács, I Zagyva, A Erdei, BG Vértessy
Nucleosides, Nucleotides and Nucleic Acids 30 (6), 369-390, 2011
362011
Proteins with Complex Architecture as Potential Targets for Drug Design: A Case Study of Mycobacterium tuberculosis
B Mészáros, J Tóth, BG Vértessy, Z Dosztányi, I Simon
PLoS computational biology 7 (7), e1002118, 2011
342011
Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release
A Maélnaési-Csizmadia, J Toéth, DS Pearson, C Heteényi, L Nyitray, ...
Journal of Biological Chemistry 282 (24), 17658-17664, 2007
342007
Structure and enzymatic mechanism of a moonlighting dUTPase
I Leveles, V Németh, JE Szabó, V Harmat, K Nyíri, AA Bendes, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2298-2308, 2013
302013
Structural characterization of arginine fingers: identification of an arginine finger for the pyrophosphatase dUTPases
GN Nagy, R Suardíaz, A Lopata, O Ozohanics, K Vékey, BR Brooks, ...
Journal of the American Chemical Society 138 (45), 15035-15045, 2016
292016
Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium
R Hirmondó, JE Szabó, K Nyíri, S Tarjányi, P Dobrotka, J Tóth, ...
DNA repair 30, 21-27, 2015
292015
Mutations decouple proton transfer from phosphate cleavage in the dutpase catalytic reaction
A Lopata, PG Jambrina, PK Sharma, BR Brooks, J Toth, BG Vertessy, ...
Acs Catalysis 5 (6), 3225-3237, 2015
272015
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