Judit Toth
Judit Toth
PI, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences
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Mechanism of blebbistatin inhibition of myosin II
M Kovács, J Tóth, C Hetényi, A Málnási-Csizmadia, JR Sellers
Journal of Biological Chemistry 279 (34), 35557-35563, 2004
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases
BG Vértessy, J Tóth
Accounts of chemical research 42 (1), 97-106, 2009
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme
J Tóth, B Varga, M Kovács, A Málnási-Csizmadia, BG Vértessy
Journal of Biological Chemistry 282 (46), 33572-33582, 2007
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase
B Varga, O Barabás, J Kovári, J Tóth, É Hunyadi-Gulyás, É Klement, ...
FEBS letters 581 (24), 4783-4788, 2007
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
I Pecsi, I Leveles, V Harmat, BG Vertessy, J Toth
Nucleic acids research 38 (20), 7179-7186, 2010
The dUTPase enzyme is essential in Mycobacterium smegmatis
I Pecsi, R Hirmondo, AC Brown, A Lopata, T Parish, BG Vertessy, J Tóth
PloS one 7 (5), e37461, 2012
Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family
J Tóth, M Kovács, F Wang, L Nyitray, JR Sellers
Journal of Biological Chemistry 280 (34), 30594-30603, 2005
Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control
JE Szabo, V Németh, V Papp-Kádár, K Nyíri, I Leveles, AA Bendes, ...
Nucleic acids research 42 (19), 11912-11920, 2014
Switch 1 mutation S217A converts myosin V into a low duty ratio motor
E Forgacs, T Sakamoto, S Cartwright, B Belknap, M Kovács, J Tóth, ...
Journal of Biological Chemistry 284 (4), 2138-2149, 2009
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
P Erdélyi, É Borsos, K Takács-Vellai, T Kovács, AL Kovács, T Sigmond, ...
Journal of cell science 124 (9), 1510-1518, 2011
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination
I Pécsi, JE Szabó, SD Adams, I Simon, JR Sellers, BG Vértessy, J Tóth
Proceedings of the National Academy of Sciences 108 (35), 14437-14442, 2011
Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool,(–)‐Blebbistatin
C Lucas‐Lopez, S Patterson, T Blum, AF Straight, J Toth, AMZ Slawin, ...
European journal of organic chemistry 2005 (9), 1736-1740, 2005
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
G Rona, M Marfori, M Borsos, I Scheer, E Takács, J Toth, F Babos, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2495-2505, 2013
Structural characterization of arginine fingers: identification of an arginine finger for the pyrophosphatase dUTPases
GN Nagy, R Suardíaz, A Lopata, O Ozohanics, K Vékey, BR Brooks, ...
Journal of the American Chemical Society 138 (45), 15035-15045, 2016
Proteins with Complex Architecture as Potential Targets for Drug Design: A Case Study of Mycobacterium tuberculosis
B Mészáros, J Tóth, BG Vértessy, Z Dosztányi, I Simon
PLoS computational biology 7 (7), e1002118, 2011
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism
G Merényi, J Kovári, J Tóth, E Takács, I Zagyva, A Erdei, BG Vértessy
Nucleosides, Nucleotides and Nucleic Acids 30 (6), 369-390, 2011
Mutations decouple proton transfer from phosphate cleavage in the dutpase catalytic reaction
A Lopata, PG Jambrina, PK Sharma, BR Brooks, J Toth, BG Vertessy, ...
Acs Catalysis 5 (6), 3225-3237, 2015
Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release
A Maélnaési-Csizmadia, J Toéth, DS Pearson, C Heteényi, L Nyitray, ...
Journal of Biological Chemistry 282 (24), 17658-17664, 2007
Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium
R Hirmondó, JE Szabó, K Nyíri, S Tarjányi, P Dobrotka, J Tóth, ...
DNA repair 30, 21-27, 2015
Structure and enzymatic mechanism of a moonlighting dUTPase
I Leveles, V Németh, JE Szabó, V Harmat, K Nyíri, AA Bendes, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2298-2308, 2013
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