Frederic Y. Bois
Frederic Y. Bois
Senior Sci Advisor & Head of Mechanistic Modelling, Certara Simcyp division
Verified email at - Homepage
Cited by
Cited by
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
S Adler, D Basketter, S Creton, O Pelkonen, J Van Benthem, V Zuang, ...
Archives of toxicology 85 (5), 367-485, 2011
Physiological pharmacokinetic analysis using population modeling and informative prior distributions
A Gelman, F Bois, J Jiang
Journal of the American Statistical Association 91 (436), 1400-1412, 1996
Adverse outcome pathways: opportunities, limitations and open questions
M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ...
Archives of toxicology 91 (11), 3477-3505, 2017
Metabolomics in toxicology and preclinical research
T Ramirez, M Daneshian, H Kamp, FY Bois, MR Clench, M Coen, ...
Altex 30 (2), 209, 2013
PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals
FY Bois, M Jamei, HJ Clewell
Toxicology 278 (3), 256-267, 2010
Statistical issues in toxicokinetic modeling: a Bayesian perspective
P Bernillon, FY Bois
Environmental Health Perspectives, 883-893, 2000
Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress
A Wilmes, A Limonciel, L Aschauer, K Moenks, C Bielow, MO Leonard, ...
Journal of proteomics 79, 180-194, 2013
Joint modeling of survival and longitudinal non‐survival data: current methods and issues. Report of the DIA Bayesian joint modeling working group
A Lawrence Gould, ME Boye, MJ Crowther, JG Ibrahim, G Quartey, ...
Statistics in medicine 34 (14), 2181-2195, 2015
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation
HA Barton, WA Chiu, R Woodrow Setzer, ME Andersen, AJ Bailer, ...
Toxicological Sciences 99 (2), 395-402, 2007
Integrated testing strategies (ITS) for safety assessment
C Rovida, M Daneshian, T Hartung
Alternatives to animal experimentation: ALTEX 32 (1), 25-40, 2015
Bayesian-optimal design via interacting particle systems
B Amzal, FY Bois, E Parent, CP Robert
Journal of the American Statistical association 101 (474), 773-785, 2006
Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans
FY Bois, L Zeise, TN Tozer
Toxicology and applied pharmacology 102 (2), 300-315, 1990
Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches
S Coecke, O Pelkonen, SB Leite, U Bernauer, JGM Bessems, FY Bois, ...
Toxicology in vitro 27 (5), 1570-1577, 2013
MCSim: a Monte Carlo simulation program
FY Bois, DR Maszle
Journal of Statistical Software 2, 1-60, 1997
Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps
G Loizou, M Spendiff, HA Barton, J Bessems, FY Bois, MB d’Yvoire, ...
Regulatory Toxicology and Pharmacology 50 (3), 400-411, 2008
PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA–EURL ECVAM ADME workshop
JG Bessems, G Loizou, K Krishnan, HJ Clewell III, C Bernasconi, F Bois, ...
Regulatory Toxicology and Pharmacology 68 (1), 119-139, 2014
Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics
A Wilmes, C Bielow, C Ranninger, P Bellwon, L Aschauer, A Limonciel, ...
Toxicology in vitro 30 (1), 117-127, 2015
Addressing human variability in next-generation human health risk assessments of environmental chemicals
L Zeise, FY Bois, WA Chiu, D Hattis, I Rusyn, KZ Guyton
Environmental health perspectives 121 (1), 23-31, 2013
GNU MCSim: Bayesian statistical inference for SBML-coded systems biology models
FY Bois
Bioinformatics 25 (11), 1453-1454, 2009
Statistical analysis of Clewell et al. PBPK model of trichloroethylene kinetics.
FY Bois
Environmental health perspectives 108 (suppl 2), 307-316, 2000
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