| Statin-induced myopathy is associated with mitochondrial complex III inhibition TJJ Schirris, GH Renkema, T Ritschel, NC Voermans, A Bilos, ... Cell metabolism 22 (3), 399-407, 2015 | 234 | 2015 |
| Brothers in arms: ABCA1-and ABCG1-mediated cholesterol efflux as promising targets in cardiovascular disease treatment SJCM Frambach, R de Haas, JAM Smeitink, GA Rongen, FGM Russel, ... Pharmacological reviews 72 (1), 152-190, 2020 | 97 | 2020 |
| Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells WMA Westerink, TJJ Schirris, GJ Horbach, WGEJ Schoonen Mutation Research/Genetic Toxicology and Environmental Mutagenesis 724 (1-2 …, 2011 | 82 | 2011 |
| Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia J Vriend, JGP Peters, TTG Nieskens, R Škovroňová, N Blaimschein, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (1), 129433, 2020 | 68 | 2020 |
| Safety of drug use in patients with a primary mitochondrial disease: an international Delphi‐based consensus MC De Vries, DA Brown, ME Allen, L Bindoff, GS Gorman, A Karaa, ... Journal of Inherited Metabolic Disease 43 (4), 800-818, 2020 | 56 | 2020 |
| Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism NAE Allard, TJJ Schirris, RJ Verheggen, FGM Russel, RJ Rodenburg, ... The Journal of Clinical Endocrinology & Metabolism 103 (1), 75-84, 2018 | 56 | 2018 |
| Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux DC Liemburg-Apers, TJJ Schirris, FGM Russel, PHGM Willems, ... Biophysical Journal 109 (7), 1372-1386, 2015 | 56 | 2015 |
| Statin lactonization by uridine 5′-diphospho-glucuronosyltransferases (UGTs) TJJ Schirris, T Ritschel, A Bilos, JAM Smeitink, FGM Russel Molecular pharmaceutics 12 (11), 4048-4055, 2015 | 53 | 2015 |
| Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention MAE Van De Wal, MJW Adjobo-Hermans, J Keijer, TJJ Schirris, ... Brain 145 (1), 45-63, 2022 | 42 | 2022 |
| Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Aβ40 (DAβ1-40) are modulated by sulfate moieties of heparin NM Timmer, TJJ Schirris, IB Bruinsma, I Otte-Höller, TH van Kuppevelt, ... Neuroscience research 66 (4), 380-389, 2010 | 35 | 2010 |
| The ketogenic diet as a therapeutic intervention strategy in mitochondrial disease C Qu, J Keijer, MJW Adjobo-Hermans, M van de Wal, T Schirris, ... The International Journal of Biochemistry & Cell Biology 138, 106050, 2021 | 28 | 2021 |
| Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity KM Weigand, TJJ Schirris, M Houweling, JJMW van den Heuvel, ... Toxicology in Vitro 56, 52-61, 2019 | 24 | 2019 |
| Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity TJJ Schirris, T Ritschel, G Herma Renkema, PHGM Willems, ... Scientific reports 5 (1), 14533, 2015 | 23 | 2015 |
| Skeletal muscle toxicity associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia L Janssen, SJCM Frambach, NAE Allard, MTE Hopman, TJJ Schirris, ... Leukemia 33 (8), 2116-2120, 2019 | 22 | 2019 |
| Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice SJCM Frambach, MAE van de Wal, PHH van den Broek, JAM Smeitink, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (6), 165727, 2020 | 19 | 2020 |
| Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells J Vriend, CA Hoogstraten, KR Venrooij, BT van den Berge, LP Govers, ... Biological Chemistry 400 (10), 1347-1358, 2019 | 15 | 2019 |
| Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition SJ Baron, MS King, ERS Kunji, TJJ Schirris Theranostics 11 (11), 5077, 2021 | 14 | 2021 |
| Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells E Peters, T Schirris, AH van Asbeck, J Gerretsen, J Eymael, A Ashikov, ... European journal of pharmacology 796, 149-157, 2017 | 12 | 2017 |
| KRIPO–a structure-based pharmacophores approach explains polypharmacological effects T Ritschel, TJJ Schirris, FGM Russel Journal of cheminformatics 6 (Suppl 1), O26, 2014 | 12 | 2014 |
| Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer S Tavoulari, TJJ Schirris, V Mavridou, C Thangaratnarajah, MS King, ... Molecular metabolism 60, 101469, 2022 | 11 | 2022 |
