Livio Trusolino

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Andrea BertottiUniversity of Torino - School of MedicineVerified email at ircc.it
francesco sassiIRCC-University of Torino School of Medicine, Laboratory of Molecular Pharmacology ItalyVerified email at ircc.it
Enzo MedicoProfessor of Histology, University of Torino and Head of the Laboratory of Oncogenomics, CandioloVerified email at ircc.it
Salvatore SienaUniversità degli Studi di Milano, Dipartimento di Oncologia, Ospedale Niguarda, Milano, ItalyVerified email at unimi.it
Andrea Sartore-BianchiClinical Molecular Oncology, Niguarda Cancer Center, Milano - ItalyVerified email at ospedaleniguarda.it
Claudio IsellaIRCCVerified email at ircc.it
Luca LazzariIFOM - FIRC Institute of Molecular OncologyVerified email at ifom.eu
Fortunato CiardielloProfessore di oncologia medica, seconda università di napoliVerified email at unina2.it
Jos JonkersProfessor at Leiden University and group leader at Netherlands Cancer Institute, Oncode InstituteVerified email at nki.nl
Simona CorsoUniversity of TorinoVerified email at ircc.it
Alessandro AMOREOspedale Regina Margherita Torino, Università degli studi TorinoVerified email at unito.it
Lorenzo CapussottiChief of the Surgical Deparment- Ospedale Mauriziano "Umberto I" TorinoVerified email at mauriziano.it
Charlotte RolnyAssociate professor of tumor biology, PI at Lund University and Karolinska Institutet, SwedenVerified email at med.lu.se
Guido SeriniProfessor, University of Torino School of Medicine | Candiolo Cancer Institute IRCCSVerified email at ircc.it
Dario RiberoDirigente Medico I livello, Divisione di Chirurgia Generale ed Oncologica, Ospedale Mauriziano Umberto IVerified email at mauriziano.it
Lodewyk WesselsProfessor of Computational Cancer BiologyVerified email at nki.nl
Massimiliano MazzoneGroup Leader, Vesalius Research CenterVerified email at vib-kuleuven.be
Andrea CasazzaDirector Biology @ Montis Bioscience, BelgiumVerified email at montisbio.com
Giuseppe Bassoprofessor of pediatrics university paduaVerified email at unipd.it
Antonio PalumboUniversità di Torino; Torino ItalyVerified email at unito.it

Livio Trusolino

Professor, University of Torino School of Medicine, Italy

Verified email at ircc.it - Homepage

Targeted anti-cancer therapies animal models oncogenic signal transduction pathways


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Patient-derived xenograft models: an emerging platform for translational cancer research M Hidalgo, F Amant, AV Biankin, E Budinská, AT Byrne, C Caldas, ... Cancer discovery 4 (9), 998-1013, 2014	1710	2014
MET signalling: principles and functions in development, organ regeneration and cancer L Trusolino, A Bertotti, PM Comoglio Nature reviews Molecular cell biology 11 (12), 834-848, 2010	1350	2010
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens FM Behan, F Iorio, G Picco, E Gonçalves, CM Beaver, G Migliardi, ... Nature 568 (7753), 511-516, 2019	1080	2019
A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer A Bertotti, G Migliardi, F Galimi, F Sassi, D Torti, C Isella, D Corà, ... Cancer discovery 1 (6), 508-523, 2011	1026	2011
Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of … A Sartore-Bianchi, L Trusolino, C Martino, K Bencardino, S Lonardi, ... The Lancet Oncology 17 (6), 738-746, 2016	997	2016
Drug development of MET inhibitors: targeting oncogene addiction and expedience PM Comoglio, S Giordano, L Trusolino Nature reviews Drug discovery 7 (6), 504-516, 2008	969	2008
Scatter-factor and semaphorin receptors: cell signalling for invasive growth L Trusolino, PM Comoglio Nature reviews cancer 2 (4), 289-300, 2002	906	2002
Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer A Bardelli, S Corso, A Bertotti, S Hobor, E Valtorta, G Siravegna, ... Cancer discovery 3 (6), 658-673, 2013	703	2013
Interrogating open issues in cancer precision medicine with patient-derived xenografts AT Byrne, DG Alférez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ... Nature Reviews Cancer 17 (4), 254-268, 2017	679	2017
Stromal contribution to the colorectal cancer transcriptome C Isella, A Terrasi, SE Bellomo, C Petti, G Galatola, A Muratore, A Mellano, ... Nature genetics 47 (4), 312-319, 2015	658	2015
A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth L Trusolino, A Bertotti, PM Comoglio Cell 107 (5), 643-654, 2001	567	2001
The genomic landscape of response to EGFR blockade in colorectal cancer A Bertotti, E Papp, S Jones, V Adleff, V Anagnostou, B Lupo, M Sausen, ... Nature 526 (7572), 263-267, 2015	476	2015
The Met tyrosine kinase receptor in development and cancer A Gentile, L Trusolino, PM Comoglio Cancer and metastasis reviews 27, 85-94, 2008	388	2008
Adaptive mutability of colorectal cancers in response to targeted therapies M Russo, G Crisafulli, A Sogari, NM Reilly, S Arena, S Lamba, A Bartolini, ... Science 366 (6472), 1473-1480, 2019	356	2019
Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3 C Sun, S Hobor, A Bertotti, D Zecchin, S Huang, F Galimi, F Cottino, ... Cell reports 7 (1), 86-93, 2014	355	2014
Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. G Tripodi, F Valtorta, L Torielli, E Chieregatti, S Salardi, L Trusolino, ... The Journal of clinical investigation 97 (12), 2815-2822, 1996	324	1996
Interactions between growth factor receptors and adhesion molecules: breaking the rules PM Comoglio, C Boccaccio, L Trusolino Current opinion in cell biology 15 (5), 565-571, 2003	322	2003
EGFR Blockade Reverts Resistance to KRAS^G12C Inhibition in Colorectal Cancer V Amodio, R Yaeger, P Arcella, C Cancelliere, S Lamba, A Lorenzato, ... Cancer discovery 10 (8), 1129-1139, 2020	318	2020
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy PM Comoglio, L Trusolino, C Boccaccio Nature Reviews Cancer 18 (6), 341-358, 2018	310	2018
HER2 activating mutations are targets for colorectal cancer treatment SM Kavuri, N Jain, F Galimi, F Cottino, SM Leto, G Migliardi, ... Cancer discovery 5 (8), 832-841, 2015	302	2015

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