Issam Ben-Sahra
Issam Ben-Sahra
E-mail megerősítve itt: northwestern.edu - Kezdőlap
Hivatkozott rá
Hivatkozott rá
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
IB Sahra, K Laurent, A Loubat, S Giorgetti-Peraldi, P Colosetti, P Auberger, ...
Oncogene 27 (25), 3576-3586, 2008
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
I Ben-Sahra, JJ Howell, JM Asara, BD Manning
Science 339 (6125), 1323-1328, 2013
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning
Science 351 (6274), 728-733, 2016
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
I Ben Sahra, C Regazzetti, G Robert, K Laurent, Y Le Marchand-Brustel, ...
Cancer research 71 (13), 4366-4372, 2011
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
I Ben Sahra, K Laurent, S Giuliano, F Larbret, G Ponzio, P Gounon, ...
Cancer research 70 (6), 2465-2475, 2010
Metformin in cancer therapy: a new perspective for an old antidiabetic drug?
I Ben Sahra, Y Le Marchand-Brustel, JF Tanti, F Bost
Molecular cancer therapeutics 9 (5), 1092-1099, 2010
The TSC-mTOR pathway regulates macrophage polarization
V Byles, AJ Covarrubias, I Ben-Sahra, DW Lamming, DM Sabatini, ...
Nature communications 4 (1), 2834, 2013
mTORC1 signaling and the metabolic control of cell growth
I Ben-Sahra, BD Manning
Current opinion in cell biology 45, 72-82, 2017
Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
AJ Covarrubias, HI Aksoylar, J Yu, NW Snyder, AJ Worth, SS Iyer, J Wang, ...
elife 5, e11612, 2016
Hypoxia decreases insulin signaling pathways in adipocytes
C Regazzetti, P Peraldi, T Grémeaux, R Najem-Lendom, I Ben-Sahra, ...
Diabetes 58 (1), 95-103, 2009
Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair
S Zhang, S Weinberg, M DeBerge, A Gainullina, M Schipma, JM Kinchen, ...
Cell metabolism 29 (2), 443-456. e5, 2019
Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production
A Longchamp, T Mirabella, A Arduini, MR MacArthur, A Das, ...
Cell 173 (1), 117-129. e14, 2018
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
AJ Covarrubias, A Kale, R Perrone, JA Lopez-Dominguez, AO Pisco, ...
Nature metabolism 2 (11), 1265-1283, 2020
Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
SJH Ricoult, JL Yecies, I Ben-Sahra, BD Manning
Oncogene 35 (10), 1250-1260, 2016
Cancer cells tune the signaling pathways to empower de novo synthesis of nucleotides
E Villa, ES Ali, U Sahu, I Ben-Sahra
Cancers 11 (5), 688, 2019
A growing role for mTOR in promoting anabolic metabolism
JJ Howell, SJH Ricoult, I Ben-Sahra, BD Manning
Biochemical Society Transactions 41 (4), 906-912, 2013
The mTORC1 signaling network senses changes in cellular purine nucleotide levels
G Hoxhaj, J Hughes-Hallett, RC Timson, E Ilagan, M Yuan, JM Asara, ...
Cell reports 21 (5), 1331-1346, 2017
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death
I Ben-Sahra, B Dirat, K Laurent, A Puissant, P Auberger, A Budanov, ...
Cell Death & Differentiation 20 (4), 611-619, 2013
Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS
M Yuan, DM Kremer, H Huang, SB Breitkopf, I Ben-Sahra, BD Manning, ...
Nature protocols 14 (2), 313-330, 2019
The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
I Ben Sahra, JF Tanti, F Bost
Autophagy 6 (5), 670-671, 2010
A rendszer jelenleg nem tudja elvégezni a műveletet. Próbálkozzon újra később.
Cikkek 1–20