Követés
Brendan D. Manning
Brendan D. Manning
E-mail megerősítve itt: hsph.harvard.edu - Kezdőlap
Cím
Hivatkozott rá
Hivatkozott rá
Év
AKT/PKB signaling: navigating downstream
BD Manning, LC Cantley
Cell 129 (7), 1261-1274, 2007
73482007
AKT/PKB signaling: navigating the network
BD Manning, A Toker
Cell 169 (3), 381-405, 2017
32362017
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
K Düvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, ...
Molecular cell 39 (2), 171-183, 2010
22372010
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
BD Manning, AR Tee, MN Logsdon, J Blenis, LC Cantley
Molecular cell 10 (1), 151-162, 2002
19302002
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas, K Lei, RL Hurley, BD Manning, JH Reiling, E Hafen, ...
Genes & development 18 (23), 2893-2904, 2004
16912004
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
J Luo, BD Manning, LC Cantley
Cancer cell 4 (4), 257-262, 2003
16882003
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee, BD Manning, PP Roux, LC Cantley, J Blenis
Current biology 13 (15), 1259-1268, 2003
15072003
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
J Huang, BD Manning
Biochemical Journal 412 (2), 179-190, 2008
14562008
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
G Hoxhaj, BD Manning
Nature Reviews Cancer 20 (2), 74-88, 2020
13802020
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw, N Bardeesy, BD Manning, L Lopez, M Kosmatka, RA DePinho, ...
Cancer cell 6 (1), 91-99, 2004
12652004
Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
AR Tee, DC Fingar, BD Manning, DJ Kwiatkowski, LC Cantley, J Blenis
Proceedings of the National Academy of Sciences 99 (21), 13571-13576, 2002
10252002
A complex interplay between Akt, TSC2 and the two mTOR complexes
J Huang, BD Manning
Biochemical Society Transactions 37 (1), 217-222, 2009
9032009
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
S Menon, CC Dibble, G Talbott, G Hoxhaj, AJ Valvezan, H Takahashi, ...
Cell 156 (4), 771-785, 2014
8462014
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
I Ben-Sahra, JJ Howell, JM Asara, BD Manning
Science 339 (6125), 1323-1328, 2013
8032013
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
CC Dibble, BD Manning
Nature cell biology 15 (6), 555-564, 2013
7932013
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning
Science 351 (6274), 728-733, 2016
7652016
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
JL Yecies, HH Zhang, S Menon, S Liu, D Yecies, AI Lipovsky, C Gorgun, ...
Cell metabolism 14 (1), 21-32, 2011
6792011
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
CC Dibble, W Elis, S Menon, W Qin, J Klekota, JM Asara, PM Finan, ...
Molecular cell 47 (4), 535-546, 2012
6702012
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ...
Nature cell biology 16 (11), 1069-1079, 2014
6662014
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
J Huang, CC Dibble, M Matsuzaki, BD Manning
Molecular and cellular biology 28 (12), 4104-4115, 2008
6582008
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Cikkek 1–20