Replication stress links structural and numerical cancer chromosomal instability RA Burrell, SE McClelland, D Endesfelder, P Groth, MC Weller, N Shaikh, ... Nature 494 (7438), 492-496, 2013 | 902 | 2013 |
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress ZT Schug, B Peck, DT Jones, Q Zhang, S Grosskurth, IS Alam, ... Cancer cell 27 (1), 57-71, 2015 | 703 | 2015 |
Neutralising antibody activity against SARS-CoV-2 VOCs B. 1.617. 2 and B. 1.351 by BNT162b2 vaccination EC Wall, M Wu, R Harvey, G Kelly, S Warchal, C Sawyer, R Daniels, ... The Lancet 397 (10292), 2331-2333, 2021 | 589 | 2021 |
Chromosomal instability confers intrinsic multidrug resistance AJX Lee, D Endesfelder, AJ Rowan, A Walther, NJ Birkbak, PA Futreal, ... Cancer research 71 (5), 1858-1870, 2011 | 512 | 2011 |
The novel mechanism of initiation of picornavirus RNA translation RJ Jackson, MT Howell, A Kaminski Trends in biochemical sciences 15 (12), 477-483, 1990 | 509 | 1990 |
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif S Germain, M Howell, GM Esslemont, CS Hill Genes & Development 14 (4), 435-451, 2000 | 350 | 2000 |
Chromosomal instability determines taxane response C Swanton, B Nicke, M Schuett, AC Eklund, C Ng, Q Li, T Hardcastle, ... Proceedings of the National Academy of Sciences 106 (21), 8671-8676, 2009 | 311 | 2009 |
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma H Miess, B Dankworth, AM Gouw, M Rosenfeldt, W Schmitz, M Jiang, ... Oncogene 37 (40), 5435-5450, 2018 | 275 | 2018 |
T cell repertoire following autologous stem cell transplantation for multiple sclerosis PA Muraro, H Robins, S Malhotra, M Howell, D Phippard, C Desmarais, ... The Journal of clinical investigation 124 (3), 1168-1172, 2014 | 270 | 2014 |
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers CF Houlihan, N Vora, T Byrne, D Lewer, G Kelly, J Heaney, S Gandhi, ... The Lancet 396 (10246), e6-e7, 2020 | 247 | 2020 |
Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism. A Kaminski, MT Howell, RJ Jackson The EMBO journal 9 (11), 3753-3759, 1990 | 242 | 1990 |
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 as an important regulator of prostate cancer cell survival S Ros, CR Santos, S Moco, F Baenke, G Kelly, M Howell, N Zamboni, ... Cancer discovery 2 (4), 328-343, 2012 | 224 | 2012 |
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration AL Nishimura, V ®upunski, C Troakes, C Kathe, P Fratta, M Howell, ... Brain 133 (6), 1763-1771, 2010 | 219 | 2010 |
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments B Peck, ZT Schug, Q Zhang, B Dankworth, DT Jones, E Smethurst, ... Cancer & metabolism 4, 1-18, 2016 | 218 | 2016 |
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies M Steckel, M Molina-Arcas, B Weigelt, M Marani, PH Warne, H Kuznetsov, ... Cell research 22 (8), 1227-1245, 2012 | 198 | 2012 |
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation L Levy, M Howell, D Das, S Harkin, V Episkopou, CS Hill Molecular and Cellular Biology 27 (17), 6068-6083, 2007 | 194 | 2007 |
UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene L Williamson, M Saponaro, S Boeing, P East, R Mitter, T Kantidakis, ... Cell 168 (5), 843-855. e13, 2017 | 192 | 2017 |
Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial MR Rigby, LA DiMeglio, MS Rendell, EI Felner, JM Dostou, SE Gitelman, ... The lancet Diabetes & endocrinology 1 (4), 284-294, 2013 | 183 | 2013 |
Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription S Ross, E Cheung, TG Petrakis, M Howell, WL Kraus, CS Hill The EMBO journal 25 (19), 4490-4502, 2006 | 183 | 2006 |
The involvement of a spliceosome component in internal initiation of human rhinovirus RNA translation A Borman, MT Howell, JG Patton, RJ Jackson Journal of General Virology 74 (9), 1775-1788, 1993 | 183 | 1993 |