| Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer CG Willett, Y Boucher, E Di Tomaso, DG Duda, LL Munn, RT Tong, ... Nature medicine 10 (2), 145-147, 2004 | 2501 | 2004 |
| Normalization of the vasculature for treatment of cancer and other diseases S Goel, DG Duda, L Xu, LL Munn, Y Boucher, D Fukumura, RK Jain Physiological reviews 91 (3), 1071-1121, 2011 | 1685 | 2011 |
| Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases F Winkler, SV Kozin, RT Tong, SS Chae, MF Booth, I Garkavtsev, L Xu, ... Cancer cell 6 (6), 553-563, 2004 | 1561 | 2004 |
| Lymphatic metastasis in the absence of functional intratumor lymphatics TP Padera, A Kadambi, E di Tomaso, CM Carreira, EB Brown, Y Boucher, ... Science 296 (5574), 1883-1886, 2002 | 1369 | 2002 |
| Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy Y Huang, J Yuan, E Righi, WS Kamoun, M Ancukiewicz, J Nezivar, ... Proceedings of the National Academy of Sciences 109 (43), 17561-17566, 2012 | 944 | 2012 |
| Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood YS Chang, E di Tomaso, DM McDonald, R Jones, RK Jain, LL Munn Proceedings of the National Academy of Sciences 97 (26), 14608-14613, 2000 | 941 | 2000 |
| Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors T Stylianopoulos, JD Martin, VP Chauhan, SR Jain, B Diop-Frimpong, ... Proceedings of the National Academy of Sciences 109 (38), 15101-15108, 2012 | 831 | 2012 |
| Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging BJ Vakoc, RM Lanning, JA Tyrrell, TP Padera, LA Bartlett, ... Nature medicine 15 (10), 1219-1223, 2009 | 816 | 2009 |
| Dissecting tumour pathophysiology using intravital microscopy RK Jain, LL Munn, D Fukumura Nature Reviews Cancer 2 (4), 266-276, 2002 | 800 | 2002 |
| Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model RK Jain, RT Tong, LL Munn Cancer research 67 (6), 2729-2735, 2007 | 715 | 2007 |
| Mechanical compression drives cancer cells toward invasive phenotype JM Tse, G Cheng, JA Tyrrell, SA Wilcox-Adelman, Y Boucher, RK Jain, ... Proceedings of the National Academy of Sciences 109 (3), 911-916, 2012 | 650 | 2012 |
| Fluid forces control endothelial sprouting JW Song, LL Munn Proceedings of the National Academy of Sciences 108 (37), 15342-15347, 2011 | 578 | 2011 |
| During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. RJ Melder, GC Koenig, BP Witwer, N Safabakhsh, LL Munn, RK Jain Nature medicine 2 (9), 992-997, 1996 | 571 | 1996 |
| Consensus guidelines for the use and interpretation of angiogenesis assays P Nowak-Sliwinska, K Alitalo, E Allen, A Anisimov, AC Aplin, R Auerbach, ... Angiogenesis, 1-108, 2018 | 554 | 2018 |
| Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells G Cheng, J Tse, RK Jain, LL Munn PLoS one 4 (2), e4632, 2009 | 535 | 2009 |
| Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre‐clinical models DAI Fukumura, DG Duda, LL Munn, RK Jain Microcirculation 17 (3), 206-225, 2010 | 524 | 2010 |
| Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal … CG Willett, Y Boucher, DG Duda, E Di Tomaso, LL Munn, RT Tong, ... Journal of clinical oncology: official journal of the American Society of …, 2005 | 495 | 2005 |
| Physical traits of cancer HT Nia, LL Munn, RK Jain Science 370 (6516), eaaz0868, 2020 | 484 | 2020 |
| Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors RB Campbell, D Fukumura, EB Brown, LM Mazzola, Y Izumi, RK Jain, ... Cancer research 62 (23), 6831-6836, 2002 | 480 | 2002 |
| Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: from mathematical modeling to bench to bedside T Stylianopoulos, LL Munn, RK Jain Trends in cancer 4 (4), 292-319, 2018 | 459 | 2018 |
Rakesh JainMassachusetts General Hospital, Harvard Medical School, Carnegie Mellon, Columbia, DelawareVerified email at steele.mgh.harvard.edu
