| Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 T Klemm, G Ebert, DJ Calleja, CC Allison, LW Richardson, JP Bernardini, ... The EMBO journal 39 (18), e106275, 2020 | 385 | 2020 |
| Structure of a HOIP/E2~ ubiquitin complex reveals RBR E3 ligase mechanism and regulation BC Lechtenberg, A Rajput, R Sanishvili, MK Dobaczewska, CF Ware, ... Nature 529 (7587), 546-550, 2016 | 180 | 2016 |
| Structural mechanisms in NLR inflammasome signaling BC Lechtenberg, PD Mace, SJ Riedl Current opinion in structural biology 29, 17-25, 2014 | 127 | 2014 |
| NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation BC Lechtenberg, DJD Johnson, SMV Freund, JA Huntington Proceedings of the National Academy of Sciences 107 (32), 14087-14092, 2010 | 116 | 2010 |
| Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis BC Lechtenberg, TA Murray-Rust, DJD Johnson, TE Adams, ... Blood, The Journal of the American Society of Hematology 122 (16), 2777-2783, 2013 | 83 | 2013 |
| An ensemble view of thrombin allostery BC Lechtenberg, SMV Freund, JA Huntington Biological chemistry 393 (9), 889-898, 2012 | 75 | 2012 |
| GpIbα interacts exclusively with exosite II of thrombin BC Lechtenberg, SMV Freund, JA Huntington Journal of molecular biology 426 (4), 881-893, 2014 | 51 | 2014 |
| Chain reactions: molecular mechanisms of RBR ubiquitin ligases TR Cotton, BC Lechtenberg Biochemical Society Transactions 48 (4), 1737-1750, 2020 | 48 | 2020 |
| Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor I Lamberto, BC Lechtenberg, EJ Olson, PD Mace, PE Dawson, SJ Riedl, ... ACS chemical biology 9 (12), 2787-2795, 2014 | 46 | 2014 |
| The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine CM Santiveri, BC Lechtenberg, MD Allen, A Sathyamurthy, AM Jaulent, ... Journal of molecular biology 382 (5), 1107-1112, 2008 | 40 | 2008 |
| Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling M Gomez-Soler, MP Gehring, BC Lechtenberg, E Zapata-Mercado, ... Journal of Biological Chemistry 294 (22), 8791-8805, 2019 | 34 | 2019 |
| Structure-guided strategy for the development of potent bivalent ERK inhibitors BC Lechtenberg, PD Mace, EH Sessions, R Williamson, R Stalder, ... ACS Medicinal Chemistry Letters 8 (7), 726-731, 2017 | 32 | 2017 |
| The elastase-PK101 structure: mechanism of an ultrasensitive activity-based probe revealed BC Lechtenberg, P Kasperkiewicz, H Robinson, M Drag, SJ Riedl ACS Chemical Biology 10 (4), 945-951, 2015 | 30 | 2015 |
| Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis outer membrane protein Ail K Shin, BC Lechtenberg, LM Fujimoto, Y Yao, SS Bartra, GV Plano, ... Science advances 5 (9), eaax5068, 2019 | 24 | 2019 |
| Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216 TR Cotton, SA Cobbold, JP Bernardini, LW Richardson, XS Wang, ... Molecular cell 82 (3), 598-615. e8, 2022 | 19 | 2022 |
| Modifications of a nanomolar cyclic peptide antagonist for the EphA4 receptor to achieve high plasma stability EJ Olson, BC Lechtenberg, C Zhao, ER de la Torre, I Lamberto, SJ Riedl, ... ACS medicinal chemistry letters 7 (9), 841-846, 2016 | 19 | 2016 |
| The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family XS Wang, TR Cotton, SJ Trevelyan, LW Richardson, WT Lee, J Silke, ... Nature Communications 14 (1), 168, 2023 | 17 | 2023 |
| insights into drug repurposing, as well as specificity and compound properties of piperidine-based SARS-CoV-2 PLpro inhibitors DJ Calleja, N Kuchel, BGC Lu, RW Birkinshaw, T Klemm, M Doerflinger, ... Frontiers in Chemistry 10, 861209, 2022 | 17 | 2022 |
| Design and characterization of a heterobifunctional degrader of KEAP1 H Chen, NH Nguyen, CM Magtoto, SA Cobbold, GM Bidgood, ... Redox Biology 59, 102552, 2023 | 16 | 2023 |
| Solution structure of the FCS zinc finger domain of the human polycomb group protein L (3) mbt‐like 2 BC Lechtenberg, MD Allen, TJ Rutherford, SMV Freund, M Bycroft Protein Science 18 (3), 657-661, 2009 | 15 | 2009 |
James A HuntingtonProfessor of Molecular Haemostasis, University of CambridgeE-mail megerősítve itt: cam.ac.uk
