Negative feedback control of neuronal activity by microglia A Badimon, HJ Strasburger, P Ayata, X Chen, A Nair, A Ikegami, P Hwang, ... Nature 586 (7829), 417-423, 2020 | 634 | 2020 |
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking CA Siciliano, H Noamany, CJ Chang, AR Brown, X Chen, D Leible, ... Science 366 (6468), 1008-1012, 2019 | 148 | 2019 |
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types S Ravindra Kumar, TF Miles, X Chen, D Brown, T Dobreva, Q Huang, ... Nature methods 17 (5), 541-550, 2020 | 143 | 2020 |
Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems X Chen, SR Kumar, CD Adams, D Yang, T Wang, DA Wolfe, CM Arokiaraj, ... Neuron 110 (14), 2242-2257. e6, 2022 | 70 | 2022 |
Adeno-associated virus toolkit to target diverse brain cells RC Challis, S Ravindra Kumar, X Chen, D Goertsen, GM Coughlin, ... Annual review of neuroscience 45, 447-469, 2022 | 60 | 2022 |
Super-resolution label-free volumetric vibrational imaging C Qian, K Miao, LE Lin, X Chen, J Du, L Wei Nature Communications 12 (1), 3648, 2021 | 38 | 2021 |
Dorsal raphe dopamine neurons signal motivational salience dependent on internal state, expectation, and behavioral context JR Cho, X Chen, A Kahan, JE Robinson, DA Wagenaar, V Gradinaru Journal of Neuroscience 41 (12), 2645-2655, 2021 | 28* | 2021 |
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain MR Chuapoco, NC Flytzanis, N Goeden, J Christopher Octeau, KM Roxas, ... Nature nanotechnology 18 (10), 1241-1251, 2023 | 27 | 2023 |
Spatial transcriptomics for profiling the tropism of viral vectors in tissues MJ Jang, GM Coughlin, CR Jackson, X Chen, MR Chuapoco, ... Nature biotechnology 41 (9), 1272-1286, 2023 | 23 | 2023 |
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates X Chen, DA Wolfe, DS Bindu, M Zhang, N Taskin, D Goertsen, TF Shay, ... Nature communications 14 (1), 3345, 2023 | 16 | 2023 |
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors TF Shay, EE Sullivan, X Ding, X Chen, S Ravindra Kumar, D Goertsen, ... Science advances 9 (16), eadg6618, 2023 | 15* | 2023 |
Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system LJ Campos, CM Arokiaraj, MR Chuapoco, X Chen, N Goeden, ... Current Research in Neurobiology, 100086, 2023 | 12 | 2023 |
Or47b plays a role in Drosophila males' preference for younger mates L Zhuang, Y Sun, M Hu, C Wu, X La, X Chen, Y Feng, X Wang, Y Hu, ... Open biology 6 (6), 160086, 2016 | 11 | 2016 |
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses A Kahan, A Greenbaum, MJ Jang, JE Robinson, JR Cho, X Chen, ... Cell reports 36 (13), 2021 | 10 | 2021 |
Myc inhibits JNK-mediated cell death in vivo J Huang, Y Feng, X Chen, W Li, L Xue Apoptosis 22, 479-490, 2017 | 9 | 2017 |
Victoria Omstead, Naz Taskin, Natalie Weed, Boaz P. Levi, Jonathan T. Ting, Cory T. Miller MR Chuapoco, NC Flytzanis, N Goeden, JC Octeau, KM Roxas, KY Chan, ... Benjamin E. Deverman, James Pickel, Lin Tian, Andrew S. Fox, Viviana Gradinaru, 2023 | 5 | 2023 |
Establishment of a Drosophila AD model X Wang, Y Zhao, Y Hu, P Ren, Y Sun, X Guo, X Huang, Y Zhu, X Chen, ... Journal of Biological Methods 3 (2), e43, 2016 | 3 | 2016 |
Intravenous functional gene transfer throughout the brain of non-human primates using AAV MR Chuapoco, NC Flytzanis, N Goeden, JC Octeau, KM Roxas, KY Chan, ... Research Square, 2023 | 2 | 2023 |
Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder TF Shay, S Jang, X Chen, B Walker, C Tebbutt, DA Wolfe, TJ Brittain, ... bioRxiv, 2024.01. 05.574399, 2024 | 1 | 2024 |
Targets for Receptor-Mediated Control of Therapeutic Biodistribution and Efficacy V Gradinaru, TF Shay, X Chen, J Seongmin US Patent App. 18/495,508, 2024 | | 2024 |