| The medicinal chemist’s toolbox: an analysis of reactions used in the pursuit of drug candidates SD Roughley, AM Jordan Journal of medicinal chemistry 54 (10), 3451-3479, 2011 | 2416 | 2011 |
| 4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ... Journal of medicinal chemistry 51 (2), 196-218, 2008 | 506 | 2008 |
| Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design BW Dymock, X Barril, PA Brough, JE Cansfield, A Massey, E McDonald, ... Journal of medicinal chemistry 48 (13), 4212-4215, 2005 | 275 | 2005 |
| Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular … PA Brough, X Barril, J Borgognoni, P Chene, NGM Davies, B Davis, ... Journal of medicinal chemistry 52 (15), 4794-4809, 2009 | 190 | 2009 |
| Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds N Baurin, R Baker, C Richardson, I Chen, N Foloppe, A Potter, A Jordan, ... Journal of chemical information and computer sciences 44 (2), 643-651, 2004 | 175 | 2004 |
| Synthesis of (−)-Histrionicotoxin by a Tandem Process GM Williams, SD Roughley, JE Davies, AB Holmes, JP Adams Journal of the American Chemical Society 121 (20), 4900-4901, 1999 | 121 | 1999 |
| How well can fragments explore accessed chemical space? A case study from heat shock protein 90: miniperspective SD Roughley, RE Hubbard Journal of medicinal chemistry 54 (12), 3989-4005, 2011 | 107 | 2011 |
| Dynamic undocking and the quasi-bound state as tools for drug discovery S Ruiz-Carmona, P Schmidtke, FJ Luque, L Baker, N Matassova, B Davis, ... Nature chemistry 9 (3), 201-206, 2017 | 88 | 2017 |
| Hsp90 inhibitors and drugs from fragment and virtual screening S Roughley, L Wright, P Brough, A Massey, RE Hubbard Fragment-Based Drug Discovery and X-Ray Crystallography, 61-82, 2011 | 74* | 2011 |
| Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products JB Murray, SD Roughley, N Matassova, PA Brough Journal of medicinal chemistry 57 (7), 2845-2850, 2014 | 70 | 2014 |
| Nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 9. Formal synthesis of (−)-pinidine and total synthesis of (−)-histrionicotoxin,(+)-histrionicotoxin … EC Davison, ME Fox, AB Holmes, SD Roughley, CJ Smith, GM Williams, ... Journal of the Chemical Society, Perkin Transactions 1, 1494-1514, 2002 | 65 | 2002 |
| Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo [2, 3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization NGM Davies, H Browne, B Davis, MJ Drysdale, N Foloppe, S Geoffrey, ... Bioorganic & medicinal chemistry 20 (22), 6770-6789, 2012 | 48 | 2012 |
| Drug discovery chemistry: a primer for the non-specialist AM Jordan, SD Roughley Drug discovery today 14 (15-16), 731-744, 2009 | 48 | 2009 |
| Establishing drug discovery and identification of hit series for the anti-apoptotic proteins, Bcl-2 and Mcl-1 JB Murray, J Davidson, I Chen, B Davis, P Dokurno, CJ Graham, R Harris, ... ACS omega 4 (5), 8892-8906, 2019 | 47 | 2019 |
| Structure-based design of agents targeting the bacterial ribosome J Bower, M Drysdale, R Hebdon, A Jordan, G Lentzen, N Matassova, ... Bioorganic & medicinal chemistry letters 13 (15), 2455-2458, 2003 | 45 | 2003 |
| Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas T Hart, AT Macias, K Benwell, T Brooks, J D’Alessandro, P Dokurno, ... Bioorganic & medicinal chemistry letters 19 (15), 4241-4244, 2009 | 44 | 2009 |
| Design and Synthesis of 56 Shape‐Diverse 3D Fragments TD Downes, SP Jones, HF Klein, MC Wheldon, M Atobe, PS Bond, ... Chemistry (Weinheim an der Bergstrasse, Germany) 26 (41), 8969, 2020 | 41 | 2020 |
| Fragment-based lead discovery BJ Davis, SD Roughley Annual reports in medicinal chemistry 50, 371-439, 2017 | 34 | 2017 |
| Application of off-rate screening in the identification of novel pan-isoform inhibitors of pyruvate dehydrogenase kinase PA Brough, L Baker, S Bedford, K Brown, S Chavda, V Chell, ... Journal of Medicinal Chemistry 60 (6), 2271-2286, 2017 | 28 | 2017 |
| Thioesterification and selenoesterification of amides via selective N–C cleavage at room temperature: N–C (O) to S/Se–C (O) interconversion MM Rahman, G Li, M Szostak Synthesis 52 (07), 1060-1066, 2020 | 21 | 2020 |
Roderick HubbardUniversity of York and Vernalis (R&D) LtdE-mail megerősítve itt: york.ac.uk
