Hein J. Wijma
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Computationally designed libraries for rapid enzyme stabilization
HJ Wijma, RJ Floor, PA Jekel, D Baker, SJ Marrink, DB Janssen
Protein Engineering, Design & Selection 27 (2), 49-58, 2014
Structure-and sequence-analysis inspired engineering of proteins for enhanced thermostability
HJ Wijma, RJ Floor, DB Janssen
Current opinion in structural biology 23 (4), 588-594, 2013
Computational redesign of enzymes for regio-and enantioselective hydroamination
R Li, HJ Wijma, L Song, Y Cui, M Otzen, Y Tian, J Du, T Li, D Niu, Y Chen, ...
Nature chemical biology 14 (7), 664-670, 2018
Enantioselective enzymes by computational design and in silico screening
HJ Wijma, RJ Floor, S Bjelic, SJ Marrink, D Baker, DB Janssen
Angewandte Chemie International Edition 54 (12), 3726-3730, 2015
Real-time conformational changes and controlled orientation of native proteins inside a protein nanoreactor
V Van Meervelt, M Soskine, S Singh, GK Schuurman-Wolters, HJ Wijma, ...
Journal of the American Chemical Society 139 (51), 18640-18646, 2017
Computational library design for increasing haloalkane dehalogenase stability
RJ Floor, HJ Wijma, DI Colpa, A Ramos‐Silva, PA Jekel, W Szymański, ...
ChemBioChem 15 (11), 1660-1672, 2014
A random-sequential mechanism for nitrite binding and active site reduction in copper-containing nitrite reductase
HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters
Journal of Biological Chemistry 281 (24), 16340-16346, 2006
Computational design gains momentum in enzyme catalysis engineering
HJ Wijma, DB Janssen
The FEBS journal 280 (13), 2948-2960, 2013
Versatile peptide C-terminal functionalization via a computationally engineered peptide amidase
B Wu, HJ Wijma, L Song, HJ Rozeboom, C Poloni, Y Tian, MI Arif, ...
ACS Catalysis 6 (8), 5405-5414, 2016
A computational library design protocol for rapid improvement of protein stability: FRESCO
HJ Wijma, MJLJ Fürst, DB Janssen
Protein engineering: Methods and protocols, 69-85, 2018
Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue
HL van Beek, HJ Wijma, L Fromont, DB Janssen, MW Fraaije
FEBS Open Bio 4, 168-174, 2014
Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks
JGE van Leeuwen, HJ Wijma, RJ Floor, JM van der Laan, DB Janssen
ChemBioChem 13 (1), 137-148, 2012
Bidirectional catalysis by copper-containing nitrite reductase
HJ Wijma, GW Canters, S de Vries, MP Verbeet
Biochemistry 43 (32), 10467-10474, 2004
Robust ω-transaminases by computational stabilization of the subunit interface
Q Meng, N Capra, CM Palacio, E Lanfranchi, M Otzen, LZ Van Schie, ...
ACS catalysis 10 (5), 2915-2928, 2020
Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase
M Schallmey, RJ Floor, B Hauer, M Breuer, PA Jekel, HJ Wijma, ...
ChemBioChem 14 (7), 870-881, 2013
A robust cosolvent-compatible halohydrin dehalogenase by computational library design
H Arabnejad, M Dal Lago, PA Jekel, RJ Floor, AMWH Thunnissen, ...
Protein Engineering, Design and Selection 30 (3), 175-189, 2017
Computationally efficient and accurate enantioselectivity modeling by clusters of molecular dynamics simulations
HJ Wijma, SJ Marrink, DB Janssen
Journal of chemical information and modeling 54 (7), 2079-2092, 2014
Protein film voltammetry of copper-containing nitrite reductase reveals reversible inactivation
HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters
Journal of the American Chemical Society 129 (27), 8557-8565, 2007
Creating a more robust 5-hydroxymethylfurfural oxidase by combining computational predictions with a novel effective library design
C Martin, A Ovalle Maqueo, HJ Wijma, MW Fraaije
Biotechnology for biofuels 11, 1-9, 2018
Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion
HJ Wijma, MJ Boulanger, A Molon, M Fittipaldi, M Huber, MEP Murphy, ...
Biochemistry 42 (14), 4075-4083, 2003
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Articles 1–20