Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ... Science 362 (6418), 1064-1069, 2018 | 744 | 2018 |
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation VG Magupalli, R Negro, Y Tian, AV Hauenstein, G Di Caprio, W Skillern, ... Science 369 (6510), eaas8995, 2020 | 245 | 2020 |
Gasdermins and their role in immunity and inflammation P Orning, E Lien, KA Fitzgerald Journal of Experimental Medicine 216 (11), 2453-2465, 2019 | 218 | 2019 |
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation D Ratner, MPA Orning, MK Proulx, D Wang, MA Gavrilin, MD Wewers, ... PLoS pathogens 12 (12), e1006035, 2016 | 118 | 2016 |
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling NJ Nilsen, GI Vladimer, J Stenvik, MPA Orning, MV Zeid-Kilani, M Bugge, ... Journal of Biological Chemistry 290 (6), 3209-3222, 2015 | 114 | 2015 |
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity P Orning, E Lien Journal of Leucocyte Biology 109 (1), 121-141, 2021 | 101 | 2021 |
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, ... Cell reports 35 (6), 2021 | 59 | 2021 |
RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages L Tao, Y Yi, Y Chen, H Zhang, P Orning, E Lien, J Jie, W Zhang, Q Xu, Y Li, ... Cell Death & Differentiation 28 (4), 1418-1433, 2021 | 54 | 2021 |
Manipulation of interleukin-1β and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence D Ratner, MPA Orning, KK Starheim, R Marty-Roix, MK Proulx, ... Journal of Biological Chemistry 291 (19), 9894-9905, 2016 | 52 | 2016 |
Inhibition of HSP90 and activation of HSF1 diminish macrophage NLRP3 inflammasome activity in alcohol‐associated liver injury A Choudhury, D Bullock, A Lim, J Argemi, P Orning, E Lien, R Bataller, ... Alcoholism: Clinical and Experimental Research 44 (6), 1300-1311, 2020 | 37 | 2020 |
Bacterial secretion systems and regulation of inflammasome activation D Ratner, MPA Orning, E Lien Journal of Leucocyte Biology 101 (1), 165-181, 2017 | 33 | 2017 |
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation P Ørning, KS Hoem, AE Coron, G Skjåk-Bræk, TE Mollnes, OL Brekke, ... Journal of Controlled Release 229, 58-69, 2016 | 29 | 2016 |
Streptolysin O induces the ubiquitination and degradation of pro-IL-1β D Hancz, E Westerlund, C Valfridsson, GM Aemero, B Bastiat-Sempe, ... Journal of Innate Immunity 11 (6), 457-468, 2019 | 22 | 2019 |
A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation MC Kiritsy, LM Ankley, J Trombley, GP Huizinga, AE Lord, P Orning, ... Elife 10, e65110, 2021 | 18 | 2021 |
A sugar rush for innate immunity P Orning, TH Flo, E Lien Cell host & microbe 24 (4), 461-463, 2018 | 5 | 2018 |
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo KE Nilsen, B Zhang, A Skjesol, L Ryan, H Vagle, MH Bøe, P Orning, ... Life Science Alliance 6 (12), 2023 | 2 | 2023 |
A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation MC Kiritsy, LM Ankley, JD Trombley, GP Huizinga, AE Lord, P Orning, ... bioRxiv, 2020.08. 12.248252, 2020 | 2 | 2020 |
Alginate Microcapsules for Cell Therapy: Effect of capsule composition on complement activation, cytokine secretion, and protein adsorption in a whole blood model MPA Ørning Institutt for bioteknologi, 2012 | 1 | 2012 |
A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation [preprint] MC Kiritsy, LM Ankley, J Trombley, GP Huizinga, AE Lord, P Orning, ... | | 2020 |
Trondheim, 2012 MPA Ørning Norwegian University of Science and Technology, 2012 | | 2012 |