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Pontus Ørning
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Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ...
Science 362 (6418), 1064-1069, 2018
7442018
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
VG Magupalli, R Negro, Y Tian, AV Hauenstein, G Di Caprio, W Skillern, ...
Science 369 (6510), eaas8995, 2020
2452020
Gasdermins and their role in immunity and inflammation
P Orning, E Lien, KA Fitzgerald
Journal of Experimental Medicine 216 (11), 2453-2465, 2019
2182019
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
D Ratner, MPA Orning, MK Proulx, D Wang, MA Gavrilin, MD Wewers, ...
PLoS pathogens 12 (12), e1006035, 2016
1182016
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
NJ Nilsen, GI Vladimer, J Stenvik, MPA Orning, MV Zeid-Kilani, M Bugge, ...
Journal of Biological Chemistry 290 (6), 3209-3222, 2015
1142015
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity
P Orning, E Lien
Journal of Leucocyte Biology 109 (1), 121-141, 2021
1012021
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, ...
Cell reports 35 (6), 2021
592021
RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages
L Tao, Y Yi, Y Chen, H Zhang, P Orning, E Lien, J Jie, W Zhang, Q Xu, Y Li, ...
Cell Death & Differentiation 28 (4), 1418-1433, 2021
542021
Manipulation of interleukin-1β and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence
D Ratner, MPA Orning, KK Starheim, R Marty-Roix, MK Proulx, ...
Journal of Biological Chemistry 291 (19), 9894-9905, 2016
522016
Inhibition of HSP90 and activation of HSF1 diminish macrophage NLRP3 inflammasome activity in alcohol‐associated liver injury
A Choudhury, D Bullock, A Lim, J Argemi, P Orning, E Lien, R Bataller, ...
Alcoholism: Clinical and Experimental Research 44 (6), 1300-1311, 2020
372020
Bacterial secretion systems and regulation of inflammasome activation
D Ratner, MPA Orning, E Lien
Journal of Leucocyte Biology 101 (1), 165-181, 2017
332017
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
P Ørning, KS Hoem, AE Coron, G Skjåk-Bræk, TE Mollnes, OL Brekke, ...
Journal of Controlled Release 229, 58-69, 2016
292016
Streptolysin O induces the ubiquitination and degradation of pro-IL-1β
D Hancz, E Westerlund, C Valfridsson, GM Aemero, B Bastiat-Sempe, ...
Journal of Innate Immunity 11 (6), 457-468, 2019
222019
A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
MC Kiritsy, LM Ankley, J Trombley, GP Huizinga, AE Lord, P Orning, ...
Elife 10, e65110, 2021
182021
A sugar rush for innate immunity
P Orning, TH Flo, E Lien
Cell host & microbe 24 (4), 461-463, 2018
52018
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo
KE Nilsen, B Zhang, A Skjesol, L Ryan, H Vagle, MH Bøe, P Orning, ...
Life Science Alliance 6 (12), 2023
22023
A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
MC Kiritsy, LM Ankley, JD Trombley, GP Huizinga, AE Lord, P Orning, ...
bioRxiv, 2020.08. 12.248252, 2020
22020
Alginate Microcapsules for Cell Therapy: Effect of capsule composition on complement activation, cytokine secretion, and protein adsorption in a whole blood model
MPA Ørning
Institutt for bioteknologi, 2012
12012
A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation [preprint]
MC Kiritsy, LM Ankley, J Trombley, GP Huizinga, AE Lord, P Orning, ...
2020
Trondheim, 2012
MPA Ørning
Norwegian University of Science and Technology, 2012
2012
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