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Jason D. Hughes
Jason D. Hughes
Computational Biologist, Merck
Verified email at merck.com
Title
Cited by
Cited by
Year
Systematic determination of genetic network architecture
S Tavazoie, JD Hughes, MJ Campbell, RJ Cho, GM Church
Nature genetics 22 (3), 281-285, 1999
32691999
Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae
JD Hughes, PW Estep, S Tavazoie, GM Church
Journal of molecular biology 296 (5), 1205-1214, 2000
13512000
Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation
FP Roth, JD Hughes, PW Estep, GM Church
Nature biotechnology 16 (10), 939-945, 1998
12701998
Activated STING in a vascular and pulmonary syndrome
Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ...
New England Journal of Medicine 371 (6), 507-518, 2014
12422014
Physiochemical drug properties associated with in vivo toxicological outcomes
JD Hughes, J Blagg, DA Price, S Bailey, GA DeCrescenzo, RV Devraj, ...
Bioorganic & medicinal chemistry letters 18 (17), 4872-4875, 2008
9582008
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
HS Kuehn, W Ouyang, B Lo, EK Deenick, JE Niemela, DT Avery, ...
Science 345 (6204), 1623-1627, 2014
8892014
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
B Lo, K Zhang, W Lu, L Zheng, Q Zhang, C Kanellopoulou, Y Zhang, Z Liu, ...
Science 349 (6246), 436-440, 2015
6792015
A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression
BA Cohen, RD Mitra, JD Hughes, GM Church
Nature genetics 26 (2), 183-186, 2000
6412000
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
JD Milner, TP Vogel, L Forbes, CA Ma, A Stray-Pedersen, JE Niemela, ...
Blood, The Journal of the American Society of Hematology 125 (4), 591-599, 2015
5642015
Are protein–protein interfaces more conserved in sequence than the rest of the protein surface?
DR Caffrey, S Somaroo, JD Hughes, J Mintseris, ES Huang
Protein Science 13 (1), 190-202, 2004
4602004
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number
JJ Lyons, X Yu, JD Hughes, QT Le, A Jamil, Y Bai, N Ho, M Zhao, Y Liu, ...
Nature genetics 48 (12), 1564-1569, 2016
3202016
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
CL Lucas, Y Zhang, A Venida, Y Wang, J Hughes, J McElwee, M Butrick, ...
Journal of Experimental Medicine 211 (13), 2537-2547, 2014
2882014
Conservation of DNA regulatory motifs and discovery of new motifs in microbial genomes
AM McGuire, JD Hughes, GM Church
Genome research 10 (6), 744-757, 2000
2852000
Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin
R Woodhouse, M Li, J Hughes, D Delfosse, J Skoletsky, P Ma, W Meng, ...
PloS one 15 (9), e0237802, 2020
2792020
Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment
Y Zhang, X Yu, M Ichikawa, JJ Lyons, S Datta, IT Lamborn, H Jing, ES Kim, ...
Journal of Allergy and Clinical Immunology 133 (5), 1400-1409. e5, 2014
2382014
Analytical validation of a hybrid capture–based next-generation sequencing clinical assay for genomic profiling of cell-free circulating tumor DNA
TA Clark, JH Chung, M Kennedy, JD Hughes, N Chennagiri, DS Lieber, ...
The Journal of Molecular Diagnostics 20 (5), 686-702, 2018
2162018
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency
B Afzali, J Grönholm, J Vandrovcova, C O'Brien, HW Sun, I Vanderleyden, ...
Nature immunology 18 (7), 813-823, 2017
1412017
siRNA off-target effects can be reduced at concentrations that match their individual potency
DR Caffrey, J Zhao, Z Song, ME Schaffer, SA Haney, RR Subramanian, ...
PloS one 6 (7), e21503, 2011
1332011
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency
IT Lamborn, H Jing, Y Zhang, SB Drutman, JK Abbott, S Munir, S Bade, ...
Journal of Experimental Medicine 214 (7), 1949-1972, 2017
1312017
ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans
JJ Lyons, Y Liu, CA Ma, X Yu, MP O’Connell, MG Lawrence, Y Zhang, ...
Journal of Experimental Medicine 214 (3), 669-680, 2017
942017
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