|If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells|
IB Roninson, EV Broude, BD Chang
Drug Resistance Updates 4 (5), 303-313, 2001
|A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents|
BD Chang, EV Broude, M Dokmanovic, H Zhu, A Ruth, Y Xuan, ...
Cancer research 59 (15), 3761-3767, 1999
|Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases|
BD Chang, K Watanabe, EV Broude, J Fang, JC Poole, TV Kalinichenko, ...
Proceedings of the National Academy of Sciences 97 (8), 4291-4296, 2000
|Role of p53 and p21 waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs|
BD Chang, Y Xuan, EV Broude, H Zhu, B Schott, J Fang, IB Roninson
Oncogene 18 (34), 4808-4818, 1999
|Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent|
BD Chang, ME Swift, M Shen, J Fang, EV Broude, IB Roninson
Proceedings of the National Academy of Sciences 99 (1), 389-394, 2002
|p21 Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells|
BD Chang, EV Broude, J Fang, TV Kalinichenko, R Abdryashitov, ...
Oncogene 19 (17), 2165-2170, 2000
|Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities|
DC Porter, E Farmaki, S Altilia, GP Schools, DK West, M Chen, BD Chang, ...
Proceedings of the National Academy of Sciences 109 (34), 13799-13804, 2012
|Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis|
ZN Demidenko, S Kalurupalle, C Hanko, CU Lim, E Broude, ...
Oncogene 27 (32), 4402-4410, 2008
|p21 Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation|
EV Broude, ME Swift, C Vivo, BD Chang, BM Davis, S Kalurupalle, ...
Oncogene 26 (48), 6954-6958, 2007
|Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor-and cycle-arrest-mediated cytoprotection|
ZN Demidenko, C Vivo, HD Halicka, CJ Li, K Bhalla, EV Broude, ...
Cell Death & Differentiation 13 (9), 1434-1441, 2006
|Structural insight into substrate and inhibitor discrimination by human P-glycoprotein|
A Alam, J Kowal, E Broude, I Roninson, KP Locher
Science 363 (6428), 753-756, 2019
|p21 (CDKN1A) is a negative regulator of p53 stability|
EV Broude, ZN Demidenko, C Vivo, ME Swift, BM Davis, ...
Cell Cycle 6 (12), 1467-1470, 2007
|Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer|
MSJ McDermott, AA Chumanevich, C Lim, J Liang, M Chen, S Altilia, ...
Oncotarget 8 (8), 12558, 2017
|Expression of CDK8 and CDK8-interacting genes as potential biomarkers in breast cancer|
E V Broude, B Gyorffy, A A Chumanevich, M Chen, M SJ McDermott, ...
Current cancer drug targets 15 (8), 739-749, 2015
|Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ2 renders tumor cells dependent on its paralogous gene COPZ1|
M Shtutman, M Baig, E Levina, G Hurteau, C Lim, E Broude, M Nikiforov, ...
Proceedings of the National Academy of Sciences 108 (30), 12449-12454, 2011
|Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-κB signaling|
CL Curry, LL Reed, E Broude, TE Golde, L Miele, KE Foreman
Molecular cancer therapeutics 6 (7), 1983-1992, 2007
|Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1|
A Alam, R Küng, J Kowal, RA McLeod, N Tremp, EV Broude, IB Roninson, ...
Proceedings of the National Academy of Sciences 115 (9), E1973-E1982, 2018
|CDK8/19 Mediator kinases potentiate induction of transcription by NFκB|
M Chen, J Liang, H Ji, Z Yang, S Altilia, B Hu, A Schronce, ...
Proceedings of the National Academy of Sciences 114 (38), 10208-10213, 2017
|Down-regulation of epidermal growth factor receptors by nerve growth factor in PC12 cells is p140trk-, Ras-, and Src-dependent|
P Lazarovici, M Oshima, D Shavit, M Shibutani, H Jiang, M Monshipouri, ...
Journal of Biological Chemistry 272 (17), 11026-11034, 1997
|Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells|
RE Gonzalez, CU Lim, K Cole, CH Bianchini, GP Schools, BE Davis, ...
Cell Cycle 10 (20), 3505-3514, 2011