Structure of the nanobody-stabilized active state of the kappa opioid receptor T Che, S Majumdar, SA Zaidi, P Ondachi, JD McCorvy, S Wang, ... Cell 172 (1), 55-67. e15, 2018 | 350 | 2018 |
Expanding the genetic code of yeast for incorporation of diverse unnatural amino acids via a pyrrolysyl-tRNA synthetase/tRNA pair SM Hancock, R Uprety, A Deiters, JW Chin Journal of the American Chemical Society 132 (42), 14819-14824, 2010 | 257 | 2010 |
Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation J Luo, R Uprety, Y Naro, C Chou, DP Nguyen, JW Chin, A Deiters Journal of the American Chemical Society 136 (44), 15551-15558, 2014 | 157 | 2014 |
7-Hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects AC Kruegel, R Uprety, SG Grinnell, C Langreck, EA Pekarskaya, ... ACS central science 5 (6), 992-1001, 2019 | 154 | 2019 |
Genetically encoding an aliphatic diazirine for protein photocrosslinking C Chou, R Uprety, L Davis, JW Chin, A Deiters Chemical Science 2 (3), 480-483, 2011 | 105 | 2011 |
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace MH Baumann, S Majumdar, V Le Rouzic, A Hunkele, R Uprety, XP Huang, ... Neuropharmacology 134, 101-107, 2018 | 88 | 2018 |
Regulation of transcription through light-activation and light-deactivation of triplex-forming oligonucleotides in mammalian cells JM Govan, R Uprety, J Hemphill, MO Lively, A Deiters ACS chemical biology 7 (7), 1247-1256, 2012 | 70 | 2012 |
Spatiotemporal control of microRNA function using light-activated antagomirs CM Connelly, R Uprety, J Hemphill, A Deiters Molecular BioSystems 8 (11), 2987-2993, 2012 | 69 | 2012 |
Genetic encoding of caged cysteine and caged homocysteine in bacterial and mammalian cells R Uprety, J Luo, J Liu, Y Naro, S Samanta, A Deiters ChemBioChem 15 (12), 1793-1799, 2014 | 60 | 2014 |
G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder AM Gutridge, MT Robins, RJ Cassell, R Uprety, KL Mores, MJ Ko, ... British journal of pharmacology 177 (7), 1497-1513, 2020 | 54 | 2020 |
Site-specific promoter caging enables optochemical gene activation in cells and animals J Hemphill, J Govan, R Uprety, M Tsang, A Deiters Journal of the American Chemical Society 136 (19), 7152-7158, 2014 | 51 | 2014 |
Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite H Lusic, R Uprety, A Deiters Organic letters 12 (5), 916-919, 2010 | 51 | 2010 |
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site R Uprety, T Che, SA Zaidi, SG Grinnell, BR Varga, A Faouzi, ST Slocum, ... Elife 10, e56519, 2021 | 49 | 2021 |
Conditional control of alternative splicing through light-triggered splice-switching oligonucleotides J Hemphill, Q Liu, R Uprety, S Samanta, M Tsang, RL Juliano, A Deiters Journal of the American Chemical Society 137 (10), 3656-3662, 2015 | 48 | 2015 |
Control of protein function through optochemical translocation H Engelke, C Chou, R Uprety, P Jess, A Deiters ACS Synthetic Biology 3 (10), 731-736, 2014 | 48 | 2014 |
Genetically encoded optical activation of DNA recombination in human cells J Luo, E Arbely, J Zhang, C Chou, R Uprety, JW Chin, A Deiters Chemical communications 52 (55), 8529-8532, 2016 | 45 | 2016 |
Kratom alkaloids, natural and semi-synthetic, show less physical dependence and ameliorate opioid withdrawal LL Wilson, S Chakraborty, SO Eans, TJ Cirino, HM Stacy, CA Simons, ... Cellular and molecular neurobiology 41, 1131-1143, 2021 | 42 | 2021 |
Cellular delivery and photochemical activation of antisense agents through a nucleobase caging strategy JM Govan, R Uprety, M Thomas, H Lusic, MO Lively, A Deiters ACS chemical biology 8 (10), 2272-2282, 2013 | 36 | 2013 |
Oxidative metabolism as a modulator of kratom’s biological actions S Chakraborty, R Uprety, ST Slocum, T Irie, V Le Rouzic, X Li, LL Wilson, ... Journal of medicinal chemistry 64 (22), 16553-16572, 2021 | 30 | 2021 |
Kratom alkaloids as probes for opioid receptor function: Pharmacological characterization of minor indole and oxindole alkaloids from kratom S Chakraborty, R Uprety, AE Daibani, VL Rouzic, A Hunkele, ... ACS chemical neuroscience 12 (14), 2661-2678, 2021 | 24 | 2021 |