Követés
Carles Galdeano
Carles Galdeano
Serra Hunter Lecturer Professor at University of Barcelona
E-mail megerősítve itt: ub.edu - Kezdőlap
Cím
Hivatkozott rá
Hivatkozott rá
Év
Structure-guided design and optimization of small molecules targeting the protein–protein interaction between the von Hippel–Lindau (VHL) E3 ubiquitin ligase and the hypoxia …
C Galdeano, MS Gadd, P Soares, S Scaffidi, I Van Molle, I Birced, ...
Journal of Medicinal Chemistry 57 (20), 8657-8663, 2014
2642014
Novel donepezil-based inhibitors of acetyl-and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
P Camps, X Formosa, C Galdeano, T Gómez, D Munoz-Torrero, ...
Journal of medicinal chemistry 51 (12), 3588-3598, 2008
2162008
Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds
P Camps, X Formosa, C Galdeano, D Munoz-Torrero, L Ramírez, ...
Journal of medicinal chemistry 52 (17), 5365-5379, 2009
2132009
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
J Frost, C Galdeano, P Soares, MS Gadd, KM Grzes, L Ellis, O Epemolu, ...
Nature communications 7 (1), 1-12, 2016
1482016
Huprine–tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer’s and prion diseases
C Galdeano, E Viayna, I Sola, X Formosa, P Camps, A Badia, MV Clos, ...
Journal of medicinal chemistry 55 (2), 661-669, 2012
1022012
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
P Camps, X Formosa, C Galdeano, T Gómez, D Muñoz-Torrero, ...
Chemico-biological interactions 187 (1-3), 411-415, 2010
962010
Group-based optimization of potent and cell-active inhibitors of the von Hippel–Lindau (VHL) E3 ubiquitin ligase: structure–activity relationships leading to the chemical probe …
P Soares, MS Gadd, J Frost, C Galdeano, L Ellis, O Epemolu, S Rocha, ...
Journal of medicinal chemistry 61 (2), 599-618, 2018
912018
Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates
E Viayna, T Gómez, C Galdeano, L Ramírez, M Ratia, A Badia, MV Clos, ...
ChemMedChem 5 (11), 1855-1870, 2010
712010
Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology
C Galdeano, A Ciulli
Future medicinal chemistry 8 (13), 1655-1680, 2016
602016
Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents
C Galdeano, E Viayna, P Arroyo, A Bidon-Chanal, J Ramon Blas, ...
Current pharmaceutical design 16 (25), 2818-2836, 2010
582010
Is NMR fragment screening fine-tuned to assess druggability of protein–protein interactions?
DM Dias, I Van Molle, MGJ Baud, C Galdeano, CFGC Geraldes, A Ciulli
ACS medicinal chemistry letters 5 (1), 23-28, 2014
562014
Shogaol–huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties
FJ Pérez-Areales, O Di Pietro, A Espargaró, A Vallverdú-Queralt, ...
Bioorganic & Medicinal Chemistry 22 (19), 5298-5307, 2014
462014
Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors
S Pouplana, A Espargaro, C Galdeano, E Viayna, I Sola, S Ventura, ...
Current Medicinal Chemistry 21 (9), 1152-1159, 2014
462014
Pharmacological inhibition of soluble epoxide hydrolase as a new therapy for Alzheimer’s disease
C Griñán-Ferré, S Codony, E Pujol, J Yang, R Leiva, C Escolano, ...
Neurotherapeutics 17 (4), 1825-1835, 2020
392020
Increasing polarity in tacrine and huprine derivatives: potent anticholinesterase agents for the treatment of myasthenia gravis
C Galdeano, N Coquelle, M Cieslikiewicz-Bouet, M Bartolini, B Pérez, ...
Molecules 23 (3), 634, 2018
252018
Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and …
J Juárez-Jiménez, E Mendes, C Galdeano, C Martins, DB Silva, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (2), 389-397, 2014
232014
Highly Diastereoselective One-Pot Synthesis of Spiro{cyclopenta[a]indene-2,2‘-indene}diones from 1-Indanones and Aromatic Aldehydes
P Camps, LR Domingo, X Formosa, C Galdeano, D González, ...
The Journal of Organic Chemistry 71 (9), 3464-3471, 2006
232006
Drugging the undruggable: targeting challenging E3 ligases for personalized medicine
C Galdeano
Future Medicinal Chemistry 9 (4), 347-350, 2017
222017
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity
I Sola, S Castellà, E Viayna, C Galdeano, MC Taylor, SY Gbedema, ...
Bioorganic & medicinal chemistry 23 (16), 5156-5167, 2015
142015
Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound
I Sola, E Viayna, T Gómez, C Galdeano, M Cassina, P Camps, M Romeo, ...
Molecules 20 (3), 4492-4515, 2015
142015
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