| A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ... Cell reports 17 (4), 1193-1205, 2016 | 629 | 2016 |
| Predicting the mutations generated by repair of Cas9-induced double-strand breaks F Allen, L Crepaldi, C Alsinet, AJ Strong, V Kleshchevnikov, P De Angeli, ... Nature biotechnology 37 (1), 64-72, 2019 | 460 | 2019 |
| Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development W Lin, E Metzakopian, YE Mavromatakis, N Gao, N Balaskas, H Sasaki, ... Developmental biology 333 (2), 386-396, 2009 | 186 | 2009 |
| ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka-Clift, AC Barros, ... Nature communications 10 (1), 87, 2019 | 160 | 2019 |
| UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs M Gozdecka, E Meduri, M Mazan, K Tzelepis, M Dudek, AJ Knights, ... Nature genetics 50 (6), 883-894, 2018 | 135 | 2018 |
| Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing FH Siddiqi, FM Menzies, A Lopez, E Stamatakou, C Karabiyik, R Ureshino, ... Nature communications 10 (1), 1817, 2019 | 107 | 2019 |
| Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages SRW Stott, E Metzakopian, W Lin, KH Kaestner, R Hen, SL Ang Journal of Neuroscience 33 (18), 8022-8034, 2013 | 99 | 2013 |
| A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer R Rad, L Rad, W Wang, A Strong, H Ponstingl, IF Bronner, M Mayho, ... Nature genetics 47 (1), 47-56, 2015 | 96 | 2015 |
| Single-cell transcriptomics of Parkinson’s disease human in vitro models reveals dopamine neuron-specific stress responses HJR Fernandes, N Patikas, S Foskolou, SF Field, JE Park, ML Byrne, ... Cell Reports 33 (2), 2020 | 89 | 2020 |
| ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms EL Wilson, E Metzakopian Cell Death & Differentiation 28 (6), 1804-1821, 2021 | 86 | 2021 |
| Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity YE Mavromatakis, W Lin, E Metzakopian, ALM Ferri, CH Yan, H Sasaki, ... Mechanisms of development 128 (1-2), 90-103, 2011 | 75 | 2011 |
| Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors E Metzakopian, W Lin, M Salmon-Divon, H Dvinge, E Andersson, ... Development 139 (14), 2625-2634, 2012 | 68 | 2012 |
| SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 K Tzelepis, E De Braekeleer, D Aspris, I Barbieri, MS Vijayabaskar, ... Nature communications 9 (1), 5378, 2018 | 65 | 2018 |
| Genome-scale CRISPRa screen identifies novel factors for cellular reprogramming J Yang, SS Rajan, MJ Friedrich, G Lan, X Zou, H Ponstingl, DA Garyfallos, ... Stem cell reports 12 (4), 757-771, 2019 | 54 | 2019 |
| A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes J De La Rosa, J Weber, MJ Friedrich, Y Li, L Rad, H Ponstingl, Q Liang, ... Nature genetics 49 (5), 730-741, 2017 | 48 | 2017 |
| Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries E Metzakopian, A Strong, V Iyer, A Hodgkins, K Tzelepis, L Antunes, ... Scientific reports 7 (1), 2244, 2017 | 43 | 2017 |
| Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation A Chabrat, G Brisson, H Doucet-Beaupré, C Salesse, M Schaan Profes, ... Nature communications 8 (1), 933, 2017 | 36 | 2017 |
| Dynamics of indel profiles induced by various CRISPR/Cas9 delivery methods M Kosicki, SS Rajan, FC Lorenzetti, HH Wandall, Y Narimatsu, ... Progress in molecular biology and translational science 152, 49-67, 2017 | 35 | 2017 |
| Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells E Metzakopian, K Bouhali, M Alvarez-Saavedra, JA Whitsett, DJ Picketts, ... Development 142 (7), 1315-1324, 2015 | 32 | 2015 |
| A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia. Cell Rep. 17, 1193–1205 K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ... J. CELREP 79, 2016 | 29 | 2016 |
